AI Article Synopsis
- The study aimed to explore how blood sugar levels (glycemia) relate to the functioning of the autonomic nervous system, using measures like brain connectivity and heart rate variability.
- Data was collected from 146 healthy adults, focusing on the correlations between glycated hemoglobin (HbA1c), brain connectivity in specific networks, and heart rate variability (HRV) metrics.
- Results showed that higher HbA1c was linked to reduced brain connectivity and lower heart rate variability, with differences observed based on age and sex, suggesting these factors should be considered in future research.
Article Abstract
Introduction: The purpose of this study was to clarify the relationships between glycemia and function of the autonomic nervous system (ANS), assessed via resting-state functional connectivity (FC) and heart-rate variability (HRV).
Methods: Data for this study were extracted from the Leipzig Study for Mind-Body-Emotion Interactions, including 146 healthy adults (114 young, 32 older). Variables of interest were glycated hemoglobin (HbA1c), resting-state FC in the salience aspect of the central-autonomic (S-CAN) and salience network (SN) and HRV (RMSSD and high-frequency HRV (HF-HRV)).
Results: HbA1c was inversely correlated with FC in the S-CAN but not SN. HbA1c was inversely correlated with HRV. Both RMSSD and log(HF-HRV) were correlated with FC in the S-CAN and SN. Age- (not sex-related) differences were observed in the Hb1Ac-FC associations (stronger in older adults) while sex- (not age-related) differences were observed in the HRV-FC (stronger in females).
Conclusions: These findings extend the diabetes literature to healthy adults in relating glycemia and brain function. The age- and sex-related differences in these relationships highlight the need to account for the potential effects of age and sex in future investigations.
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| http://dx.doi.org/10.1016/j.neurobiolaging.2024.05.007 | DOI Listing |
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