AI Article Synopsis
- The study examined how chronic unpredictable mild stress affects cytokine levels and complement system activity in rats over several weeks.
- Key findings included an increase in IL-10 levels and a decrease in IL-4 levels throughout the stress periods, particularly after 2, 3, and 4 weeks of stress exposure.
- The percentage of C3 component lysis increased at first during stress but returned to control levels by the end of the study, indicating that stress affects the immune response in a complex manner.
Article Abstract
The parameters of the cytokine profile and functional activity of the complement system in the blood of rats were studied during different time periods of chronic unpredictable mild stress using a model of sequentially alternating low-intensity stress effects for 1, 2, 3, and 4 weeks. In the dynamics of observation, a general tendency towards multidirectional fluctuations in the concentration of cytokines was revealed: an increase in IL-10, but a decrease in IL-4 in comparison with the control. Statistically significant changes in the level of IL-10 were noted after 2, 3, and 4 weeks, IL-4 - after 2 and 4 weeks of stress loads. The percentage of lysis of the C3 component in rats gradually increased by the 2nd week of chronic stress, but then decreased and practically did not differ from the control values (intact animals) by the end of the study. These results illustrate the specificity of changes in the indicators of the C component of the complement system and the cytokine profile of the blood reflecting activity of the cellular and humoral components of the immune response in rats exposed to repeated stress factors of different origins and duration.
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