AI Article Synopsis
- Acute COVID-19 infection leads to elevated levels of neurofilament light chain (NfL), indicating potential damage to the nervous system.
- A study of 103 COVID-19 patients revealed that NfL levels are significantly influenced by various circulating inflammatory markers, such as cytokines and chemokines.
- These findings suggest that NfL could serve as a useful marker for neuronal damage linked to the inflammation caused by COVID-19.
Article Abstract
Acute coronavirus disease 2019 (COVID-19) is paralleled by a rise in the peripheral levels of neurofilament light chain (NfL), suggesting early nervous system damage. In a cohort of 103 COVID-19 patients, we studied the relationship between the NfL and peripheral inflammatory markers. We found that the NfL levels are significantly predicted by a panel of circulating cytokines/chemokines, including CRP, IL-4, IL-8, IL-9, Eotaxin, and MIP-1ß, which are highly up-regulated during COVID-19 and are associated with clinical outcomes. Our findings show that peripheral cytokines influence the plasma levels of the NfL, suggesting a potential role of the NfL as a marker of neuronal damage associated with COVID-19 inflammation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11311410 | PMC |
| http://dx.doi.org/10.3390/ijms25158259 | DOI Listing |
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