AI Article Synopsis

Article Abstract

Leishmaniasis is an infectious disease caused by protozoa of the genus , which is endemic in certain areas of Europe, such as southern Spain. The disease manifests in various clinical phenotypes, including visceral, cutaneous, mucosal, or asymptomatic leishmaniasis. This diversity in clinical outcomes may be influenced by the host immune response, with human leukocyte antigen (HLA) molecules playing a crucial role in determining susceptibility and progression of the infection. This study explores the association between specific HLA variants and infection. We recruited four cohorts: a control group, asymptomatic individuals, patients with symptomatic disease, and cohabitants of infected individuals. HLA typing was performed for all participants, followed by an association analysis with infection status and disease progression. Our findings indicate that the HLA-B*38 and HLA-C*03 alleles are associated with protection against infection. These results contribute to a better understanding of the disease's progression, offer potential for new therapeutic approaches such as vaccines, and expand the existing knowledge in the literature.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11311343PMC
http://dx.doi.org/10.3390/ijms25158205DOI Listing

Publication Analysis

Top Keywords

southern spain
8
analysis hla
4
hla alleles
4
alleles cohorts
4
cohorts patients
4
patients infected
4
infected southern
4
spain leishmaniasis
4
leishmaniasis infectious
4
disease
4

Similar Publications

Aim And Objectives: To describe nurses' perceptions of sexual healthcare for people with physical and/or intellectual disabilities.

Background: Nurses are responsible for meeting the fundamental needs of people with physical and/or intellectual disabilities, yet there are still issues when it comes to their sexuality. Sexual assistants can help people with physical and/or intellectual disabilities to meet their sexual needs, but little is known about these invisible, unregulated care providers.

View Article and Find Full Text PDF

Background: Tuberculosis vaccine trials using disease as the primary endpoint are large, time consuming, and expensive. An earlier immunological measure of the protection against disease would accelerate tuberculosis vaccine development. We aimed to assess whether the effectiveness of the Bacillus Calmette-Guérin (BCG) vaccine for prevention of Mycobacterium tuberculosis infection was consistent with that for prevention of tuberculosis disease.

View Article and Find Full Text PDF

The development of disease-modifying therapies (DMTs) for the treatment of multiple sclerosis (MS) has been highly successful in recent decades. It is now widely accepted that early initiation of DMTs after disease onset is associated with a better long-term prognosis. However, the question of when and how to de-escalate or discontinue DMTs remains open and critical.

View Article and Find Full Text PDF

Objective: This clinical case describes a multidisciplinary retreatment of a patient with anterior fixed dental prostheses (FDPs) using minimally invasive restorations and a biologically oriented preparation technique (BOPT).

Clinical Considerations: A 56-year-old female patient, treated 30 years ago with a metal-ceramic FDP due to dental agenesis, presented a misfit prosthesis at the gingival margin, black spaces, and food retention at the pontics. Notably, tooth number 2.

View Article and Find Full Text PDF

The risk of high-biomass HABs: Triggers and dynamics of a non-toxic bloom of Prorocentrum micans in Chilean Patagonia.

Sci Total Environ

December 2024

Centro Oceanográfico de Vigo, Instituto Español de Oceanografía (IEO-CSIC), Vigo, Spain.

Harmful algal blooms (HABs) of toxin-producing microalgae are recurrent in Patagonian fjord systems. Like toxigenic HABs, high-biomass harmful algal blooms (HB-HABs) have important socio-economic repercussions, but most studies have focused on the former. Here we report the formation and development of an intense HB-HAB of Prorocentrum micans that occurred in Northwest Chilean Patagonia in the late summer (February-March) of 2022.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!