AI Article Synopsis
- - Cadmium (Cd) is toxic to cells, causing oxidative stress and damage, prompting research into natural antioxidants to help counteract these effects.
- - This study specifically looked at the protective abilities of melatonin (MLT), Vitamin E (VitE), and Trolox against Cd toxicity in various human cell lines, using the MTT assay to measure cell viability.
- - Results showed Vitamin E was the most effective at providing protection, but MLT also significantly reduced toxicity, especially at higher levels of Cd exposure, indicating both could be useful in reducing oxidative stress from Cd.
Article Abstract
Cadmium (Cd) toxicity poses a significant threat to cellular health, leading to oxidative stress and cell damage. Antioxidant agents, particularly those of natural origin, have been studied as a potential alternative for mitigating heavy metal toxicity. This study aimed to evaluate the cytoprotective effects of the antioxidant melatonin (MLT) in comparison with Vitamin E (VitE) and Trolox against Cd-induced cellular toxicity. The MTT assay was employed to assess cell viability in neuronal SH-SY5Y, colorectal HCT 116, and hepatic HepG2 cell lines. The results showed that all three antioxidants offered some level of protection against Cd toxicity, with Vitamin E proving to be the most effective. MLT also demonstrated a substantial cytoprotective effect, especially at the highest Cd concentration of 30 µM. These findings suggest that MLT, alongside Vit E and Trolox, could be valuable in mitigating the detrimental effects of Cd exposure by reducing the oxidative stress in these cellular models.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11312335 | PMC |
| http://dx.doi.org/10.3390/ijms25158055 | DOI Listing |
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