Three-section landslides are renowned for their immense size, concealed development process, and devastating impact. This study conducted physical model tests to simulate one special geological structure called a three-section-within landslide. The failure process and precursory characteristics of the tested samples were meticulously analyzed using video imagery, micro-seismic (MS) signals, and acoustic emission (AE) signals, with a focus on event activity, intensity, and frequency. A novel classification method based on AE waveform characteristics was proposed, categorizing AE signals into burst signals and continuous signals. The findings reveal distinct differences in the evolution of these signals. Burst signals appeared exclusively during the crack propagation and failure stages. During these stages, the cumulative AE hits of burst signals increased gradually, with amplitude rising and then declining. High-amplitude burst signals were predominantly distributed in the middle- and high-frequency bands. In contrast, cumulative AE hits of continuous signals escalated rapidly, with amplitude monotonously increasing, and high-amplitude continuous signals were primarily distributed in the low-frequency band. The emergence of burst signals and high-frequency AE signals indicated the generation of microcracks, serving as early-warning indicators. Notably, the early-warning points of AE signals were detected earlier than those of video imagery and MS signals. Furthermore, the early-warning point of burst signals occurred earlier than those of continuous signals, and the early-warning point of the classification method preceded that of overall AE signals.
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http://dx.doi.org/10.3390/s24154947 | DOI Listing |
Cell Commun Signal
January 2025
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, 315211, China.
Autophagy is essential for maintaining material balance and energy circulation and plays a critical role as a regulatory mechanism in tissue regeneration. However, current studies primarily describe this phenotype, with limited exploration of its molecular mechanisms. In this study, we provided the first evidence that autophagy is required for intestinal regeneration in Apostichopus japonicus and identified a previously unrecognized regulatory mechanism involved in this process.
View Article and Find Full Text PDFiScience
January 2025
IRCCS E. Medea Scientific Institute, Epilepsy Unit, 31015 Conegliano (TV), Italy.
Temporal lobe epilepsy (TLE) is characterized by alterations of brain dynamic on a large-scale associated with altered cognitive functioning. Here, we aimed at analyzing dynamic reconfiguration of brain activity, using the neural fingerprint approach, to delineate subject-specific characteristics and their cognitive correlates in TLE. We collected 10 min of resting-state scalp-electroencephalography (EEG, 128 channels), free from epileptiform activity, from 68 TLE patients and 34 controls.
View Article and Find Full Text PDFNature
January 2025
Perimeter Institute for Theoretical Physics, Waterloo, Ontario, Canada.
Adv Sci (Weinh)
December 2024
Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Fudan University, Shanghai, 200032, China.
Focal cortical dysplasia (FCD) is a highly heterogeneous neurodevelopmental malformation, the underlying mechanisms of which remain largely elusive. In this study, personalized dorsal and ventral forebrain organoids (DFOs/VFOs) are generated derived from brain astrocytes of patients with FCD type II (FCD II). The pathological features of dysmorphic neurons, balloon cells, and astrogliosis are successfully replicated in patient-derived DFOs, but not in VFOs.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2024
Department of Chemistry, Institut - Courtois, Quebec Center for Advanced Materials (QCAM), and Regroupement Québécois sur les Matériaux de Pointe (RQMP), Université de Montréal, Montréal, Quebec H3C 3J7, Canada.
Myocardial infarction (MI) is the leading cause of death and disability worldwide. It occurs when a thrombus forms after an atherosclerotic plaque bursts, obstructing blood flow to the heart. Prompt and accurate diagnosis is crucial for improving patient survival.
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