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Malaria: biochemical, physiological, diagnostic, and therapeutic updates.
PeerJ
March 2024
Department of Medical Biochemistry & Molecular Biology, Armed Forces College of Medicine, Cairo, Egypt.
Background: Malaria has been appraised as a significant vector-borne parasitic disease with grave morbidity and high-rate mortality. Several challenges have been confronting the efficient diagnosis and treatment of malaria.
Method: Google Scholar, PubMed, Web of Science, and the Egyptian Knowledge Bank (EKB) were all used to gather articles.
Malaria in pregnancy in India: a 50-year bird's eye.
Front Public Health
November 2023
Parasite and Host Biology Group, ICMR-National Institute of Malaria Research, New Delhi, India.
Introduction: In 2021, India contributed for ~79% of malaria cases and ~ 83% of deaths in the South East Asia region. Here, we systematically and critically analyzed data published on malaria in pregnancy (MiP) in India.
Methods: Epidemiological, clinical, parasitological, preventive and therapeutic aspects of MiP and its consequences on both mother and child were reviewed and critically analyzed.
Malaria is a vector-borne tropical infection caused by protozoa of the genus and is transmitted by the bite of an infected Anopheles mosquito. The disease is commonly characterized by fever, edema, thrombocytopenia, hypoglycemia, anemia, and myalgias; however, the infection's cutaneous presentations are not commonly emphasized and tend to be overlooked. A literature search was conducted that focused on the various skin pathologies that malaria patients have been noted to present with using case reports and currently available literature.
View Article and Find Full Text PDFA detailed kinetic model of glycolysis in Plasmodium falciparum-infected red blood cells for antimalarial drug target identification.
J Biol Chem
September 2023
Department of Biochemistry, Stellenbosch University, Matieland, South Africa; Molecular Cell Biology, Vrije Universiteit, Amsterdam, The Netherlands. Electronic address:
Upon infection by the malaria parasite Plasmodium falciparum, the glycolytic rate of a red blood cell increases up to 100-fold, possibly contributing to lactic acidosis and hypoglycemia in patients with severe malaria. This dramatic increase in glucose uptake and metabolism was correctly predicted by a newly constructed detailed enzyme kinetic model of glucose metabolism in the trophozoite-infected red blood cell. Subsequently, we expanded the model to simulate an infected red blood cell culture, including the different asexual blood-stage forms of the malaria parasite.
View Article and Find Full Text PDFSevere malaria in Gabon: epidemiological, clinical and laboratory features in Amissa Bongo Hospital of Franceville.
Malar J
March 2023
Unité Ecologie Evolution et Résistances Parasitaires (UNEEREP), Centre International de Recherches Médicales de Francevillev, BP 769, Franceville, Gabon.
Article Synopsis
- Malaria is a significant health threat, causing over half a million deaths annually, primarily in children under five in sub-Saharan Africa; this study aims to analyze severe malaria cases at a hospital in Franceville.
- An observational study was conducted over 10 months, focusing on patients of all ages with confirmed severe malaria, revealing that out of 1065 cases, 220 were classified as severe, with a high prevalence among young children.
- The study identified key symptoms associated with severe malaria, such as neurological disorders and severe anemia, and highlighted risk factors for mortality; understanding these patterns is crucial for improving early intervention and treatment strategies.
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