AI Article Synopsis
- - The study aimed to assess how effective, safe, and tolerable lacosamide therapy is for treating focal seizures in young children aged 1 month to 4 years.
- - Results showed that about 58% of children saw a reduction in seizures after 3 months, with a higher success rate for those starting lacosamide compared to those who added it later. Additionally, over a year, there was a notable improvement in the children's development.
- - The therapy had a retention rate of 72.7%, but some children experienced mild adverse effects such as vomiting and drowsiness, leading to a few withdrawals; overall, it was considered effective and safe for this age group.
Article Abstract
Aims: To evaluate the efficacy, safety, and tolerability of adjunctive lacosamide therapy against focal seizures in young children (1 month - 4 years).
Methods: This non-randomized, open-label, and self-controlled real-world study included 105 children (1 month-4 years) with focal seizures treated with adjunctive lacosamide therapy at Children's Hospital of Chongqing Medical University.
Results: (1) The 50% response rates at 3, 6, 9, and 12 months of follow-up were 58.1%, 61.0%, 57.1%, and 56.2%, while the seizure-free rates were 27.6%, 34.3%, 32.4%, and 37.1%, respectively. The 50% response rate of the first addition of lacosamide for focal seizures was much higher than the second and later added treatment at 3 months (p = 0.038). After 1 year of follow-up, these children showed an improvement in neurodevelopmental levels (p < 0.05). (2) Lacosamide retention rate was 72.7% (64/88) after 1 year of follow-up. Lack of efficacy and serious adverse events were independent risk factors for the lacosamide retention rate. (3) During adjunctive lacosamide therapy, 13 (12.4%) patients reported adverse events and five (4.7%) patients withdrew due to adverse events, including vomiting drowsiness, ataxia (0.94%), neck itching with eczema (0.94%), irritability (1.88%), and gastrointestinal discomfort (0.94%).
Conclusion: Adjunctive lacosamide therapy was effective, safe, and well-tolerated in young Chinese children with focal seizures in this study.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11315674 | PMC |
| http://dx.doi.org/10.1111/cns.14917 | DOI Listing |
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