AI Article Synopsis
- Circular RNAs (circRNAs) are unique RNA molecules formed by reverse splicing, and they play significant roles in cancer progression by affecting the STAT3 signaling pathway.
- Research indicates that the expression of circRNAs related to STAT3 is often disrupted in various cancers, where they can either inhibit tumors or promote their growth.
- This review highlights the need for further exploration of the relationship between circRNAs and the STAT3 pathway, suggesting that understanding this interaction could lead to new cancer treatment strategies.
Article Abstract
Circular RNAs (circRNAs) are endogenous covalently closed single-stranded RNAs produced by reverse splicing of pre-mRNA. Emerging evidence suggests that circRNAs contribute to cancer progression by modulating the oncogenic STAT3 signaling pathway, which plays key roles in human malignancies. STAT3 signaling-related circRNAs expression appears to be extensively dysregulated in diverse cancer types, where they function either as tumor suppressors or oncogenes. However, the biological effects of STAT3 signaling-related circRNAs and their associations with cancer have not been systematically studied before. Given this, shedding light on the interaction between circRNAs and STAT3 signaling pathway in human malignancies may provide several novel insights into cancer therapy. In this review, we provide a comprehensive introduction to the molecular mechanisms by which circRNAs regulate STAT3 signaling in cancer progression, and the crosstalk between STAT3 signaling-related circRNAs and other signaling pathways. We also further discuss the role of the circRNA/STAT3 axis in cancer chemotherapy sensitivity.
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| http://dx.doi.org/10.1016/j.bbagrm.2024.195051 | DOI Listing |
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