Dynamical descriptions and modeling of natural systems have generally focused on fixed points, with saddles and saddle-based phase-space objects such as heteroclinic channels or cycles being central concepts behind the emergence of quasistable long transients. Reliable and robust transient dynamics observed for real, inherently noisy systems is, however, not met by saddle-based dynamics, as demonstrated here. Generalizing the notion of ghost states, we provide a complementary framework that does not rely on the precise knowledge or existence of (un)stable fixed points, but rather on slow directed flows organized by ghost sets in ghost channels and ghost cycles. Moreover, we show that the appearance of these novel objects is an emergent property of a broad class of models typically used for description of natural systems.
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http://dx.doi.org/10.1103/PhysRevLett.133.047202 | DOI Listing |
Sci Rep
January 2025
Faculty of Electronic Information and Physics, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China.
Accurate segmentation of retinal blood vessels from retinal images is crucial for detecting and diagnosing a wide range of ophthalmic diseases. Our retinal blood vessel segmentation algorithm enhances microfine vessel extraction, improves edge texture clarity, and normalizes vessel distribution. It stabilizes neural network training for complex retinal vascular features.
View Article and Find Full Text PDFTheranostics
January 2025
The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen, 518172, China.
Chemotherapy is essential for treating tumors, including head and neck cancer (HNC). However, the toxic side effects of chemotherapeutic drugs limit their widespread use. Therefore, a targeted delivery system that can transport the drug to the pathological site while minimizing damage to healthy tissues is urgently needed.
View Article and Find Full Text PDFJ Biol Chem
December 2024
Université Côte d'Azur, CNRS, Inserm, Institut Biologie Valrose, Nice, France; Laboratory of Excellence for RBC, LABEX GR-Ex, Paris, France. Electronic address:
KCNN4, a Ca-activated K channel, is involved in various physiological and pathological processes. It is essential for epithelial transport, immune system, and other physiological mechanisms, but its activation is also involved in cancer pathophysiology as well as red blood cell (RBC) disorders. The activation of KCNN4 in RBC leads to loss of KCl and water, a mechanism known as the "Gardos effect" described 70 years ago.
View Article and Find Full Text PDFSensors (Basel)
December 2024
College of Computer Science and Technology, Changchun University, Changchun 130022, China.
Autophagy
December 2024
Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, University of Mons, Mons, Belgium.
Renal proximal tubules are a primary site of injury in metabolic diseases. In obese patients and animal models, proximal tubular epithelial cells (PTECs) display dysregulated lipid metabolism, organelle dysfunctions, and oxidative stress that contribute to interstitial inflammation, fibrosis and ultimately end-stage renal failure. Our research group previously pointed out AMP-activated protein kinase (AMPK) decline as a driver of obesity-induced renal disease.
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