For continuous-time Markov chains and open unimolecular chemical reaction networks, we prove that any two stationary currents are linearly related upon perturbations of a single edge's transition rates, arbitrarily far from equilibrium. We extend the result to nonstationary currents in the frequency domain, provide and discuss an explicit expression for the current-current susceptibility in terms of the network topology, and discuss possible generalizations. In practical scenarios, the mutual linearity relation has predictive power and can be used as a tool for inference or model proof testing.
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http://dx.doi.org/10.1103/PhysRevLett.133.047401 | DOI Listing |
Molecules
January 2025
Independent Researcher, 1802 Stanford Avenue, Duluth, MN 55811, USA.
The development of chirality descriptors for quantitative chirality structure-activity relationship (QCSAR) modeling has always attracted attention, owing to the importance of chiral molecules in pharmaceutical, agriculture, food, and fragrance industries, and environmental toxicology. The utility of a multidimensional space of novel relative chirality indices (RCIs) in the QCSAR modeling of twenty CCR2 antagonists is reported upon in this paper. The numerical characterization of chirality by the RCI approach gives a large pool of chirality descriptors with different degrees of mutual correlation (the correlation coefficient among the computed descriptors varied from 0.
View Article and Find Full Text PDFHealthcare (Basel)
January 2025
Faculty of Medicine Ramathibodi hospital, Mahidol University, Nakhon Pathom 10400, Thailand.
Background: Sexual satisfaction is vital for the sexual health and well-being of both cervical cancer patients and their spouses. Sexual dissatisfaction can arise from negative treatment, making it important to examine the factors that influence sexual satisfaction.
Objective: The purpose of this study was to explore the factors affecting the sexual satisfaction of Thai women with cervical cancer after complete treatment and their spouses.
J Acoust Soc Am
January 2025
Department of Electronics Engineering, Pusan National University, Busan, South Korea.
The amount of information contained in speech signals is a fundamental concern of speech-based technologies and is particularly relevant in speech perception. Measuring the mutual information of actual speech signals is non-trivial, and quantitative measurements have not been extensively conducted to date. Recent advancements in machine learning have made it possible to directly measure mutual information using data.
View Article and Find Full Text PDFAmino Acids
January 2025
Faculty of Natural Sciences, University of SS Cyril and Methodius, 91701, Trnava, Slovakia.
Four aliphatic amino acids-α-aminobutyric acid (AABA), β-aminobutyric acid (BABA), α-aminoisobutyric acid (AAIBA) and β-aminoisobutyric acid (BAIBA) were investigated in water as a solvent by two quantum chemical methods. B3LYP hybrid version of DFT was used for geometry optimization and a full vibrational analysis of neutral molecules, their cations and anions in the canonical and zwitterionic forms (6 forms for each species). Ab initio DLPNO-CCSD(T) method was applied in the geometry pre-optimized by B3LYP.
View Article and Find Full Text PDFHealth Place
January 2025
MRC Epidemiology Unit, University of Cambridge, Box 285 Institute of Metabolic Science, CB2 0QQ, Cambridge, UK.
Background: Diet and physical activity are important determinants of energy balance, body weight and chronic health conditions. Peoples' health and behaviour are shaped by their environment. For example, the availability of unhealthy takeaway food in residential neighbourhoods and the ability to easily walk to a range of local destinations (high "walkability") influence diets and physical activity levels.
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