AI Article Synopsis

  • Immune responses during pneumococcal carriage help protect against Streptococcus pneumoniae colonization and infection, with a study measuring specific IgG levels and opsonic titers in adults with and without type 2 diabetes.
  • The study included 176 samples, with findings showing similar IgG concentrations against various serotypes for both groups but higher opsonic titers in non-diabetic individuals, particularly for serotypes 19F and 9V.
  • The results suggest that while antibody production is comparable for both capsular polysaccharide and protein antigens in diabetic and non-diabetic individuals, the functional protective capacity of these antibodies differs significantly between the two groups.

Article Abstract

Immune response elicited during pneumococcal carriage has been shown to protect against subsequent colonization and infection by Streptococcus pneumoniae. The study was designed to measure the baseline serotype-specific anti-capsular IgG concentration and opsonic titers elicited in response to asymptomatic carriage in adults with and without type 2-diabetes. Level of IgG to capsular polysaccharide was measured in a total of 176 samples (124 with type 2 diabetes and 52 without type 2 diabetes) against serotype 1, 19F, 9V, and 18C. From within 176 samples, a nested cohort of 39 samples was selected for measuring the functional capacity of antibodies by measuring opsonic titer to serotypes 19F, 9V, and 18C. Next, we measured levels of IgG to PspA in 90 samples from individuals with and without diabetes (22 non-diabetes and 68 diabetes). Our results demonstrated comparable IgG titers against all serotypes between those with and without type 2-diabetes. Overall, we observed higher opsonic titers in those without diabetes as compared to individuals with diabetes for serotypes 19F and 9V. The opsonic titers for 19F and 9V significantly negatively correlated with HbA1c. For 19F, 41.66% (n = 10) showed opsonic titers ≥ 1:8 in the diabetes group as compared to 66.66% (n = 10) in the non-diabetes group. The percentage was 29.6% (n = 7) vs 66.66% (n = 10) for 9V and 70.83% (n = 17) vs 80% (n = 12) for 18C in diabetes and non-diabetes groups respectively. A comparable anti-PspA IgG (p = 0.409) was observed in those with and without diabetes, indicating that response to protein antigen is likely to remain intact in those with diabetes. In conclusion, we demonstrated comparable IgG titers to both capsular polysaccharide and protein antigens in those with and without diabetes, however, the protective capacity of antibodies differed between the two groups.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11315336PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0306921PLOS

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  • The study included 176 samples, with findings showing similar IgG concentrations against various serotypes for both groups but higher opsonic titers in non-diabetic individuals, particularly for serotypes 19F and 9V.
  • The results suggest that while antibody production is comparable for both capsular polysaccharide and protein antigens in diabetic and non-diabetic individuals, the functional protective capacity of these antibodies differs significantly between the two groups.
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