This paper introduces a ranking and selection approach to psychoacoustic and psychophysical experimentation, with the aim of identifying top-ranking samples in listening experiments with minimal pairwise comparisons. We draw inspiration from sports tournament designs and propose to adopt modified knockout (KO) tournaments. Two variants of modified KO tournaments are described, which adapt the tree selection sorting algorithm and the replacement selection algorithm known from computer science. To validate the proposed method, a listening experiment is conducted, where binaural renderings of seven chamber music halls are compared regarding loudness and reverberance. The rankings obtained by the modified KO tournament method are compared to those obtained from a traditional round-robin (RR) design, where all possible pairs are compared. Moreover, the paper presents simulations to illustrate the method's robustness when choosing different parameters and assuming different underlying data distributions. The study's findings demonstrate that modified KO tournaments are more efficient than full RR designs in terms of the number of comparisons required for identifying the top ranking samples. Thus, they provide a promising alternative for this task. We offer an open-source implementation so that researchers can easily integrate KO designs into their studies.
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Alzheimers Dement
December 2024
School of Electrical Engineering and Computer Science Gwangju Institute of Science and Technology, Gwangju 61005, Gwangju, Korea, Republic of (South).
Background: Early-stage dementia, Mild Cognitive Impairment (MCI), is challenging to diagnose since it is a transient condition distinct from complete cognitive collapse. Recent clinical research studies have identified that balance impairments can be a significant indicator for predicting dementia in older adults. Accordingly, we aimed to identify key balance biomarkers using wearable inertial sensors for early detection of dementia/MCI.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Bordeaux Population Health Research Center, Inserm U1219, University of Bordeaux, Bordeaux, France.
Background: Diet is a primary source of exposure to chemicals in the general population. Dietary contaminants originate from food production (e.g.
View Article and Find Full Text PDFBackground: Strokes affect 15 million people worldwide annually, including 5% of patients over the age of 75, making them a leading cause of death and disability, especially in elderly patients with cognitive impairment. Mnemonics have been developed in multiple languages to inform the public how to recognize stroke signs, including the English "BEFAST." For Spanish-speaking populations, the mnemonics "AHORA" and "RAPIDO" are both circulated with pictorial brochures.
View Article and Find Full Text PDFBackground: Late-onset Alzheimer's disease (AD) arises from interactions between genetic (nature) and environmental/behavioral (nurture) factors, but their relative contributions are not well defined. With the development of sensitive cognitive tasks for early detection and the growing applications of machine learning to AD research, there are unprecedented opportunities to uncover the most salient genetic and environmental/behavioral factors for preclinical AD risk. Our previous studies show that generalization performance--the ability to apply prior learning to new contexts--is a cognitive risk marker for preclinical AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Background: Not all people with neuropathological evidence of Alzheimer's disease (AD) manifest clinical symptoms in life (cognitive resilience). We aimed to identify genetic and epigenetic signatures of cognitive resilience, utilizing data from brain donors with neuropathological evidence of AD who were either symptomatic or asymptomatic in life.
Method: Among brain donors with neuropathologically-confirmed AD (364 asymptomatic/cognitively resilient and 490 symptomatic) from the Boston University AD Research Center, Framingham Heart Study-where we generated our own data-as well as the Religious Orders Study and Rush Memory and Aging Project, we utilized genome-wide genetic array data, genome-wide DNA methylation array data and RNA sequencing data.
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