AI Article Synopsis
- Angiogenesis, regulated by vascular endothelial growth factor (VEGF), plays a significant role in cancer progression, yet anti-VEGF therapies have had limited success.
- Two specific VEGFA single nucleotide polymorphisms (SNPs), rs833068GA and rs25648CC, were found to be linked to angiogenesis markers and influenced breast cancer-specific survival, particularly in estrogen receptor (ER)-negative cases.
- Additional associations were observed between the rs699947CA and rs3025039CC genotypes and tumor characteristics, indicating that certain VEGF SNPs may have implications for patient outcomes that warrant further investigation.
Article Abstract
Angiogenesis is recognized as a hallmark of cancer, and vascular endothelial growth factor (VEGF) is a key regulator of the angiogenic process and is related to cancer progression. Anti-VEGF therapy has been tried but with limited success and without useful stratification for angiogenesis markers. Further, the landscape of VEGF single nucleotide polymorphisms (SNPs) in breast cancer and their clinical relevance is not well studied, and their relation to tissue-based angiogenesis markers has not been explored. Here, we studied a selection of VEGFA SNPs in nontumor lymph nodes from a population-based breast cancer cohort (n = 544), and their relation to clinicopathologic variables, vascular tissue metrics, and breast cancer-specific survival. Two of the SNP candidates (rs833068GA genotype and rs25648CC genotype) showed associations with angiogenesis tissue markers, and the VEGFA rs833068GA genotype was associated with breast cancer-specific survival among ER-negative cases. We also found trends of association between the rs699947CA genotype and large tumor diameter and ER-negative tumors, and between the rs3025039CC genotype and large tumor diameter. Our findings indicate some associations between certain VEGF SNPs, in particular the rs833068GA genotype, and both vascular metrics and patient survival. These findings and their potential implications need to be validated by independent studies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310850 | PMC |
| http://dx.doi.org/10.1002/2056-4538.12393 | DOI Listing |
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