A facile synthetic method for direct C(sp)-H bond trifluoromethylation of 3-methylene-isoindolin-1-ones under visible-light-induced metal-free conditions is presented. This protocol features mild reaction conditions, broad substrate scope and excellent functional group tolerance, resulting in a range of structurally diverse trifluoromethylated products in good to excellent yields.
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| http://dx.doi.org/10.1039/d4ob01046a | DOI Listing |
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