Derivatization has been tremendously utilized in the field of drug discovery for optimizing the pharmacological properties and improving safety, efficacy and selectivity. Schiff's bases (AD1-AD11) are synthesized through amantadine condensation with different aldehydes and ketones. Fourier transform infrared, H NMR, C NMR, TLC, liquid chromatography mass spectrometry analysis, studies, molecular docking and antiviral activity through hemagglutinin test were performed for evaluation of new compounds. AD2, 3 and 9-11 showed greater antiviral activity than the parent drug. Among all derivatives, AD2 and AD3 exhibited good potential against α-amylase while AD7 and AD10 showed stronger inhibition against α-glucosidase. So, it is concluded that the most potent derivatives can be used as lead compounds in novel drug design of antiviral antidiabetic agents.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486214 | PMC |
| http://dx.doi.org/10.1080/17568919.2024.2385294 | DOI Listing |
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