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Alzheimers Dement

December 2024

1 Aga Khan University, Brain and Mind Institute, 3rd Parklands Avenue, Nairobi, Kenya, Nairobi, Nairobi, Kenya.

Background: In 2023, the World Health Organization (WHO) presented the Mental Health Gap Action Programmes to avert Dementia. In this publication, the WHO presented a high certainty that physical activity interventions prevent Dementia. The organization presented low levels of certainty that psychosocial interventions, non-pharmaceutical interventions, depression, and anxiety treatments are effective for Dementia prevention in low-income and middle-income countries (LMICs).

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The brain develops most rapidly during pregnancy and early neonatal months. While prior electrophysiological studies have shown that aperiodic brain activity undergoes changes across infancy to adulthood, the role of gestational duration in aperiodic and periodic activity remains unknown. In this study, we aimed to bridge this gap by examining the associations between gestational duration and aperiodic and periodic activity in the EEG power spectrum in both neonates and toddlers.

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Background: Oxytocin function is associated with a range of human traits and is often indexed by common polymorphisms of the receptor gene OXTR. Little is known however about the functional significance of these polymorphisms.

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Background: Population studies confirm mothers with intellectual disability have poorer antenatal outcomes than other mothers but less is known about any differences in sociodemographic characteristics between these groups.

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Mind the Gap: A Neural Network Framework for Imputing Genotypes in Non-Model Species.

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Reduced representation sequencing (RRS) has proven to be a cost-effective solution for sequencing subsets of the genome in non-model species for large-scale studies. However, the targeted nature of RRS approaches commonly introduces large amounts of missing data, leading to reduced statistical power and biased estimates in downstream analyses. Genotype imputation, the statistical inference of missing sites across the genome, is a powerful alternative to overcome the caveats associated with missing sites.

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