AI Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a tendency to spread quickly, leading to a poor prognosis, especially when perineural invasion (PNI) occurs.
- PNI is a condition where cancer cells invade surrounding nerves early in PDAC progression, which contributes significantly to pain and complicates treatment.
- The review discusses the pain associated with PNI, outlines its six specific progression steps, and highlights the need for new technologies to improve research and treatment approaches for PDAC.
Article Abstract
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant tumor with a high metastatic potential. Perineural invasion (PNI) occurs in the early stages of PDAC with a high incidence rate and is directly associated with a poor prognosis. It involves close interaction among PDAC cells, nerves and the tumor microenvironment. In this review, we detailed discuss PNI-related pain, six specific steps of PNI, and treatment of PDAC with PNI and emphasize the importance of novel technologies for further investigation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307098 | PMC |
| http://dx.doi.org/10.3389/fonc.2024.1421067 | DOI Listing |
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