Neuron-Specific Enolase as a Biological Marker for Welders' Pneumoconiosis.

Objective: The aim of the study is to investigate the relationship between serum neuron-specific enolase (NSE) and welders' pneumoconiosis, through chest x-ray and serum NSE.

Methods: The exposed group included 37 welders. The nonexposed group included 38 administrative workers. Both groups underwent history taking, clinical examination, chest x-ray, serum chromium, and serum neuron-specific enolase. Air sampling was done for total suspended particles, respirable particles, and welding fumes.

Results: All the air samples were within the national threshold limit values. Chest x-ray abnormalities were found in eight welders (21.6%), and included reticular opacities, scattered nodules or ground-glass opacities. Serum chromium and NSE were significantly higher among welders. Serum NSE correlated positively with the duration of exposure and serum chromium level among welders.

Conclusions: Serum NSE can be used as a biomarker for early detection of welders' pneumoconiosis.