Check out this study on the gender disproportion in the incidence of CRC among younger patients in India.
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| http://dx.doi.org/10.1200/GO.24.00220 | DOI Listing |
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Implications of Artificial Intelligence for Colorectal Cancer in Young Populations.
J Surg Oncol
December 2024
Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
A considerable amount of recent research has focused on the role of artificial intelligence (AI) in colorectal cancer (CRC), aiming to improve outcomes in CRC. However, AI for young onset colorectal cancer (yoCRC)-defined as colorectal cancer in patients less than 50 years old-is not nearly as explored, and its role in the prevention, detection, and management of yoCRC remains largely unknown. To address this gap, we performed an integrative review on AI in yoCRC.
View Article and Find Full Text PDFColorectal cancer survival in Mexico: Leveraging a national health insurance database.
Cancer Epidemiol
November 2024
Center for Research on Population Health, National Institute of Public Health, Mexico City, Mexico; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, USA. Electronic address:
Article Synopsis
- The study assessed 5-year survival rates for colorectal cancer patients in Mexico who were treated under Seguro Popular, a public health insurance system.
- It involved 1418 patients diagnosed between 2013 and 2016, revealing an overall survival rate of 50% and noting that 78.1% were diagnosed at advanced stages (III and IV).
- Findings emphasized the importance of early screening, particularly as younger patients with metastatic disease had a poorer prognosis compared to older patients.
Demographic Characteristics and Survival in Young-Onset Colorectal Neuroendocrine Neoplasms.
Biomedicines
October 2024
Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Background/objectives: Recent epidemiological studies have revealed an upward trend in young-onset colorectal cancer (YOCRC) overall, whereas specific data on young-onset colorectal neuroendocrine neoplasms (YONEN) remain limited. This study investigated the demographic characteristics and survival trends in YONEN and compared these with those of young-onset colorectal adenocarcinoma (YOADC), the most common histologic subtype of YOCRC.
Methods: A retrospective analysis was conducted from 2000 to 2019 using the Surveillance, Epidemiology, and End Results (SEER) database.
Two Decades of Progress in Personalized Medicine of Colorectal Cancer in Serbia-Insights from the Institute for Oncology and Radiology of Serbia.
Biomedicines
October 2024
Clinic for Medical Oncology, Institute for Oncology and Radiology of Serbia, 11000 Belgrade, Serbia.
Background: It is projected that, by 2040, the number of new cases of colorectal cancer (CRC) will increase to 3.2 million, and the number of deaths to 1.6 million, highlighting the need for prevention strategies, early detection and adequate follow-up.
View Article and Find Full Text PDFAtypical Exon 2/3 Mutants G48C, Q43K, and E37K Present Oncogenic Phenotypes Distinct from Characterized NRAS Variants.
Cells
October 2024
Disease Molecular Biology and Epigenetics Laboratory, National Institute of Molecular Biology and Biotechnology, University of the Philippines Diliman, Quezon City 1101, Philippines.
NRAS belongs to the RAS family of GTPases. In colorectal cancer (CRC), NRAS mutations are rare compared to KRAS, but may lead to worse outcomes. We report the functional characterization of the novel NRAS mutants-G48C, Q43K, and E37K-identified in Filipino young-onset CRC patients.
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