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A combination of topical and systemic administration of brimonidine is neuroprotective in the murine optic nerve crush model. | LitMetric

AI Article Synopsis

  • - Glaucoma, a condition that damages retinal ganglion cells (RGC), was studied to evaluate the neuroprotective effects of brimonidine, which can lower intraocular pressure and potentially protect these cells.
  • - In the experiment, 41 mice had their optic nerves crushed and were divided into three groups receiving different treatments: saline, topical brimonidine, or a combination of topical and intraperitoneal (IP) brimonidine injections.
  • - Results showed that mice receiving both topical and IP brimonidine had significantly higher RGC survival rates compared to those receiving only saline or just topical brimonidine.

Article Abstract

Unlabelled: Glaucoma is a multifactorial optic neuropathy that primarily affecting retinal ganglion cells (RGC). Brimonidine is an intraocular pressure-lowering drug with reported neuroprotective properties. This study aimed to compare the neuroprotective effects of topical and intraperitoneal (IP) brimonidine on RGCs from different retinal segments in a murine optic nerve crush (ONC) model.

Methods: forty-one Balb/c mice underwent unilateral ONC and were divided into three study groups: fifteen animals received saline drops twice per day and two additional IP injections of saline; fourteen mice received brimonidine drops twice per day; and 12 mice received brimonidine eye drops twice per day and two additional IP brimonidine injections. Animals were sacrificed seven days post-ONC, and immunohistochemical staining of retinal whole mounts was performed using neuronal NeuN and GFAP staining. Microscopic pictures of the central, middle, and peripheral regions of the retina were taken. The density of the retinal cells was assessed.

Results: The total RGC density after ONC and RGC densities in all retinal eccentricities were significantly higher in the brimonidine eye drop and IP combination treatment group than in the saline drop + saline IP, and brimonidine drop treatment groups.

Conclusions: brimonidine eye drops supplemented with IP brimonidine injections improved RGC survival in a preclinical model of ONC.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309405PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0308671PLOS

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