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Sex-specific maladaptive responses to acute stress upon in utero THC exposure are mediated by dopamine.
Pharmacol Res
December 2024
Dept. Biomedical Sciences, Div. Neuroscience and Clinical Pharmacology, University of Cagliari, Italy. Electronic address:
Article Synopsis
- * Research demonstrates that male rats exposed to THC during pregnancy exhibit altered dopamine activity and increased vulnerability to stress, affecting their sensorimotor functions.
- * The study found that the HPA axis's regulation of dopamine neurons differs by sex, influencing stress responses and sensorimotor gating, with potential for therapeutic interventions to correct these disruptions.
Exploring Endocannabinoid System: Unveiling New Roles in Modulating ER Stress.
Antioxidants (Basel)
October 2024
Department of Pharmacy, University of Salerno, Via G. Paolo II, Fisciano, 84084 Salerno, Italy.
The endoplasmic reticulum (ER) is the organelle mainly involved in maintaining cellular homeostasis and driving correct protein folding. ER-dependent defects or dysfunctions are associated with the genesis/progression of several pathological conditions, including cancer, inflammation, and neurodegenerative disorders, that are directly or indirectly correlated to a wide set of events collectively named under the term "ER stress". Despite the recent increase in interest concerning ER activity, further research studies are needed to highlight all the mechanisms responsible for ER failure.
View Article and Find Full Text PDFPsycho-Neuro-EndocrinE-Immunology Therapy of Cancer, Autoimmunity, Geriatric Disorders, Covid-19, and Hypertension.
Methods Mol Biol
November 2024
Pontificia Universitad Catolica, Buenos Aires, Argentina.
Despite the great number of experimental investigations in the area of psycho-neuro-endocrine-immunology showing that endocrine, nervous, and immune systems cannot be in vivo physiologically separated, the diagnosis and therapies of the pathologies of these three functional biological systems continue to be separately performed from a clinical practice point of view. The separation between experimental and clinical medicine became dramatic after the discovery of more than 10 human molecules provided by anti-inflammatory and antitumor activity, completely devoid of any toxicity, which may be subdivided into three fundamental classes, consisting of the pineal indole, beta-carboline, and methoxy-kynuramine hormones. Moreover, human systemic diseases, including cancer, autoimmunity, and cardiovascular pathologies, despite their different pathogenesis and symptomatology, are commonly characterized by a progressive decline in the endogenous production of pineal hormones, endocannabinoids, and Ang 1-7, with a consequent inflammatory status and diminished natural resistance against cancer.
View Article and Find Full Text PDFMyogenic Classical Endocannabinoids, Their Targets and Activity.
Biochemistry (Mosc)
October 2024
Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
This review focuses on the recently discovered specific action of two classical endocannabinoids (ECs), 2-arachidonoylglycerol (2-AG) and arachidonoyl ethanolamide (AEA), in the case of their synthesis and degradation in skeletal muscles; in other words, this review is dedicated to properties and action of the myoendocannabinoid (myoEC) pool. Influence of this pool is considered at three different levels: at the level of skeletal muscles, motor synapses, and also at the level of the whole organism, including central nervous system. Special attention is paid to the still significantly underestimated and intriguing ability of ECs to have positive effect on energy exchange and contractile activity of muscle fibers, as well as on transmitter secretion in motor synapses.
View Article and Find Full Text PDFGray matter volume differences based on sex in first-episode drug-naive patients with major depressive disorder and its molecular analysis.
Neuroreport
December 2024
Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan.
This study analyzed whether gray matter volume (GMV) differences exist between the sexes in patients with major depressive disorder (MDD) and explored the relationships between these differences and neurotransmitter systems. This study enrolled 190 first-episode drug-naive patients with MDD and 293 healthy controls. All participants underwent T1-weighted high-resolution MRI.
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