AI Article Synopsis

  • - Approximately two-thirds of asthma patients have allergies, and probiotics along with tryptophan metabolites are being explored as treatments for allergic asthma.
  • - In this study, the probiotic strain CCFM1274 was identified for its ability to produce high levels of indole-3-carboxaldehyde (I3C) and was tested in a mouse model of allergic asthma.
  • - The results indicated that CCFM1274 treatment led to reduced weight loss and mortality in mice, improved lung inflammation, decreased specific IgE levels, and positively altered gut microbiota, suggesting it may help manage allergic asthma symptoms.

Article Abstract

Approximately two-thirds of patients with asthma, a common inflammatory airway disease, are thought to present with allergies. Probiotics and tryptophan metabolites are becoming increasingly important in treating allergic asthma. This study aimed to identify potential probiotic strains and tryptophan metabolites that could alleviate asthma symptoms. Based on fermentation experiments, we evaluated variations in probiotic capacity to metabolize tryptophan. Of the eight tested strains, subsp. CCFM1274 produced relatively high levels of indole-3-carboxaldehyde (I3C). A mouse model of allergic asthma was established by oral administration of ovalbumin (OVA) and was subjected to oral administration of probiotics. The results demonstrated that treatment with CCFM1274 reduced the tendency for body weight loss and mortality in OVA-induced asthmatic mice. Ingestion of CCFM1274 improved the infiltration of perivascular and peribronchial inflammatory cells in the lung sections stained with hematoxylin and eosin (H&E). This outcome was accompanied by a reduction in the serum levels of OVA-specific immunoglobulin E (OVA-sIgE) and in the levels of IL-10 and IL-17 in the bronchoalveolar lavage fluid (BALF). The linear discriminant analysis effect size (LEfSe) of the gut microbiota showed that CCFM1274 increased the relative abundance of Bifidobacterium. In conclusion, CCFM1274 remodeled intestinal tryptophan metabolism in mice and contributed to the improvement of allergic asthma.

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Source
http://dx.doi.org/10.1039/d4fo01079eDOI Listing

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