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An applied noise model for low-loss EELS maps.
Ultramicroscopy
January 2025
Nanopatterning-Nanoanalysis-Photonic Materials Group, Department of Physics, Paderborn University, Warburgerstr. 100, Paderborn, 33098, Germany. Electronic address:
Electron energy-loss spectroscopy (EELS) performed in a scanning transmission electron microscope (STEM) is susceptible to noise, just like every other measurement. EELS measurements are also affected by signal blurring, related to the energy distribution of the electron beam and the detector point spread function (PSF). Moreover, the signal blurring caused by the detector introduces correlation effects, which smooth the noise.
View Article and Find Full Text PDFIntegrating single-cell multimodal epigenomic data using 1D-convolutional neural networks.
Bioinformatics
January 2025
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, United States.
Motivation: Recent experimental developments enable single-cell multimodal epigenomic profiling, which measures multiple histone modifications and chromatin accessibility within the same cell. Such parallel measurements provide exciting new opportunities to investigate how epigenomic modalities vary together across cell types and states. A pivotal step in using this type of data is integrating the epigenomic modalities to learn a unified representation of each cell, but existing approaches are not designed to model the unique nature of this data type.
View Article and Find Full Text PDFProne Lateral Transpsoas Approach to the Spine: A Technical Guide for Mastery.
Int J Spine Surg
January 2025
Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA
Background: The single-position prone transpsoas (PTP) lateral interbody fusion represents an alternative approach to the traditional lateral lumbar interbody fusion (LLIF) typically performed with the patient in the lateral decubitus position. Advantages of PTP surgery include improved segmental lordosis, single-position surgery, and ease of performing posterior techniques as needed. However, the learning curve of PTP is distinct from that of traditional LLIF surgery performed with the patient in the lateral decubitus position.
View Article and Find Full Text PDFJoint action partners modulate the first step of an action sequence to communicate a distal goal.
Acta Psychol (Amst)
January 2025
Department of Linguistics, Cognitive Science, and Semiotics, Aarhus University, Jens Chr. Skous Vej 2, 1485-638 Aarhus, Denmark; Interacting Minds Centre, Aarhus University, Jens Chr. Skous Vej 2, 1485-638 Aarhus, Denmark. Electronic address:
When two co-actors perform a joint action, they often communicatively modulate their instrumental actions so as to facilitate each other's predictions of their immediate, proximal goals. Here, we ask whether co-actors would also engage in such "sensorimotor communication" for distal goals, specifically those that result from a two-step action sequence. To address this question, we asked pairs of participants to work together to deliver an animated box to one of two delivery locations displayed on a computer screen.
View Article and Find Full Text PDFEpisodic and associative memory from spatial scaffolds in the hippocampus.
Nature
January 2025
Department of Brain and Cognitive Sciences and McGovern Institute, MIT, Cambridge, MA, USA.
Hippocampal circuits in the brain enable two distinct cognitive functions: the construction of spatial maps for navigation, and the storage of sequential episodic memories. Although there have been advances in modelling spatial representations in the hippocampus, we lack good models of its role in episodic memory. Here we present a neocortical-entorhinal-hippocampal network model that implements a high-capacity general associative memory, spatial memory and episodic memory.
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