AI Article Synopsis
- Tubular structures play a crucial role in biological systems, facilitating communication between cells.
- Researchers have created an artificial supramolecular channel that mimics natural gap junctions, using both hydrophobic and hydrophilic components.
- This new channel design helps to inhibit tumor cell invasion by blocking cell migration, offering a potential strategy for enhancing chemotherapy.
Article Abstract
Tubular structures exist broadly in biological systems and exhibit important functions including mediating cellular communications. The construction of artificial analogues in living cells would provide a new strategy for chemotherapy. In this report, a kind of supramolecular channel has been constructed within intercellular gaps by mimicking the assembly process and structure of natural gap junctional channels, which consist of hydrophobic tubular modules located in the adjacent cell membranes and hydrophilic modules within the extracellular space. The assembly of the channels was driven by electrostatic interactions. The channels could inhibit tumor cell invasion by preventing cell migration.
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| http://dx.doi.org/10.1021/jacs.4c05959 | DOI Listing |
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