AI Article Synopsis
- Patients on anti-TNF-α drugs for ankylosing spondylitis (AS) should be closely monitored for symptoms like purpuric and ischemic skin lesions to catch potential drug-induced issues early.
- A case study highlighted a 38-year-old woman who developed skin lesions after starting adalimumab, leading to a diagnosis of vasculitis linked to the medication.
- Stopping adalimumab and switching to other treatments like glucocorticoids and cyclophosphamide successfully resolved her skin issues, emphasizing the need to be aware of medication side effects in AS patients.
Article Abstract
Clinical Key Message: In patients receiving anti-TNF-α drugs for ankylosing spondylitis, monitoring purpuric and ischemic skin lesions is crucial. This case underscores the significance of identifying and addressing drug-induced vasculitis while stressing the necessity for prompt evaluation and exploration of alternative treatment options to safeguard patient well-being.
Abstract: The case discusses a 38-year-old female with a history of ankylosing spondylitis (AS) who presented with skin lesions, including purpuric skin lesions and ischemia of her right foot digits, after initiating treatment with adalimumab. After excluding other potential causes, such as infections and malignancies, the patient received a diagnosis of moderate-sized vascular vasculitis associated with adalimumab use. Discontinuation of adalimumab and treatment with high dose glucocorticoids and intravenous pulse of cyclophosphamide resulted in the resolution of her ischemic lesions. This case underscores the importance of considering drug-related side effects in patients with new skin lesions, particularly in the context of rheumatic diseases such as AS.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11305868 | PMC |
| http://dx.doi.org/10.1002/ccr3.9244 | DOI Listing |
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