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Survival impact of pre-transplant local treatments in liver transplant recipients with BCLC stage A hepatocellular carcinoma. | LitMetric

Survival impact of pre-transplant local treatments in liver transplant recipients with BCLC stage A hepatocellular carcinoma.

Am J Cancer Res

Division of General Surgery, Department of Surgery, Wan Fang Hospital, Taipei Medical University No. 111, Sec. 3, Xinglong Road, Wenshan District, Taipei 116, Taiwan.

Published: July 2024

AI Article Synopsis

  • - The study assessed how different pre-transplant local treatments affect the survival of liver transplant recipients with BCLC Stage A Hepatocellular Carcinoma, using data from Taiwan between 2012 and 2018.
  • - Three patient groups were analyzed: local treatments, hepatectomy, and combined treatments, with overall mortality rates showing hepatectomy having the lowest rates compared to the other methods during a median follow-up of 3.92 years.
  • - The results indicated that hepatectomy leads to better survival outcomes than local treatments or combined approaches, emphasizing its importance in treatment planning for patients with this type of liver cancer.

Article Abstract

This study aimed to evaluate the impact of different pre-transplant local treatments on the survival of liver transplantation (LTx) recipients with BCLC Stage A Hepatocellular Carcinoma (HCC). We analyzed data from the Taiwan Cancer Registry and National Health Insurance Research Databases spanning 2012 to 2018. Employing propensity score matching, patients were categorized into three groups: those receiving local treatments (180 patients), hepatectomy (179 patients), and combined treatments (180 patients). The primary outcomes were overall mortality and HCC-specific death, assessed using time-varying Cox regression models and Kaplan-Meier survival analysis. During a median follow-up period of 3.92 years, all-cause mortality rates were observed as 74.44% for local treatments, 42.46% for hepatectomy, and 65.00% for combined treatments. HCC-specific mortality rates followed a similar pattern at 65.00%, 39.11%, and 59.44%, respectively. Adjusted hazard ratios demonstrated significantly elevated mortality risks associated with local and combined treatments compared to hepatectomy. Notably, the 2-year overall and HCC-specific survival rates were highest in the hepatectomy group, surpassing those observed in both the combined treatment and local treatment groups. The findings of our study highlight that for patients with BCLC Stage A HCC, undergoing hepatectomy prior to LTx is associated with superior survival outcomes compared to solely local treatments. This underscores the importance of considering hepatectomy as a vital component of the treatment strategy in this patient population.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11301294PMC
http://dx.doi.org/10.62347/BXDX8100DOI Listing

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