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Protective effect of N-acetylcysteine against hepatocellular carcinoma in hepatitis B virus carriers. | LitMetric

Protective effect of N-acetylcysteine against hepatocellular carcinoma in hepatitis B virus carriers.

Am J Cancer Res

Division of General Surgery, Department of Surgery, Wan Fang Hospital, Taipei Medical University No. 111 Section 3, Xinglong Road, Wenshan District, Taipei 116, Taiwan.

Published: July 2024

AI Article Synopsis

  • Hepatitis B virus (HBV) infection significantly increases the risk of hepatocellular carcinoma (HCC) through genomic integration and chronic inflammation.
  • A study utilizing Taiwan's National Health Insurance Research Database involving over 1 million chronic HBV carriers found that N-acetylcysteine (NAC) users have a much lower risk of developing HCC compared to non-users.
  • The research indicated a dose-response effect, showing that higher usage of NAC correlates with a reduced incidence of HCC, especially when taken at doses greater than 1.4 defined daily doses (DDDs).

Article Abstract

Hepatitis B virus (HBV) infection is a leading risk factor for hepatocellular carcinoma (HCC), contributing to cancer development through direct genomic integration and chronic inflammation. N-acetylcysteine (NAC), known for its antioxidant properties, is widely utilized in cancer prevention. However, clinical evidence regarding its protective effect against HCC in HBV carriers remains sparse. In this retrospective cohort study spanning 2008 to 2018, we utilized Taiwan's National Health Insurance Research Database (NHIRD) to include 1,061,174 chronic HBV carriers. Participants were stratified into NAC users and non-users using Propensity Score Matching. We assessed the incidence of HCC in both cohorts, examining the relationship between NAC usage duration and HCC incidence, and evaluating the dose-response effect. NAC users exhibited a significantly lower risk of developing HCC (adjusted hazard ratio [aHR]: 0.38; 95% confidence interval [CI]: 0.36-0.40; P < 0.0001). A dose-response relationship was evident, with higher cumulative defined daily doses (cDDDs) of NAC correlating with reduced HCC risk, revealing a significant trend (P < 0.0001). Notably, a daily NAC intensity of > 1.4 DDDs was associated with a decreased risk of HCC in HBV patients. Our results demonstrate that the use of NAC, in a dose-dependent manner, is intricately linked with a diminished incidence of HCC in individuals chronically infected with the HBV.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11301295PMC
http://dx.doi.org/10.62347/QLHG1014DOI Listing

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