AI Article Synopsis
- * Analysis of 161 relevant studies reveals a diverse application of microfluidic chips, including oocyte culture, embryo manipulation, and the reconstitution of organ statuses, notably in placenta and fetal research.
- * The review highlights advancements in materials and methods for using microfluidic chips in reproductive studies and emphasizes the need for more research to address existing challenges and improve reproductive system understanding.
Article Abstract
The female reproductive system is essential to women's health, human reproduction and societal well-being. However, the clinical translation of traditional research models is restricted due to the uncertain effects and low efficiency. Emerging evidence shows that microfluidic chips provide valuable platforms for studying the female reproductive system, while no paper has ever comprehensively discussed the topic. Here, a total of 161 studies out of 14,669 records are identified in PubMed, Scopus, Web of Science, ScienceDirect and IEEE Xplore databases. Among these, 61 studies focus on oocytes, which further involves culture, cell surgeries (oocyte separation, rotation, enucleation, and denudation), evaluation and cryopreservation. Forty studies investigate embryo manipulation via microfluidic chips, covering fertilization, cryopreservation and functional evaluation. Forty-six studies reconstitute both the physiological and pathological statuses of organs, mostly involved in placenta and fetal membrane research. Fourteen studies perform drug screening and toxicity testing. In this review, we summarize the current application of microfluidic chips in studying the female reproductive system, the advancements in materials and methods, and discuss the future challenges. The present evidence suggests that microfluidic chips-assisted reproductive system reconstruction is promising and more studies are urgently needed.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303079 | PMC |
| http://dx.doi.org/10.7150/thno.97301 | DOI Listing |
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