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The interactivity and ubiquity of digital technologies are exerting a significant impact on the knowledge creation in information technology (KC-IT) projects. According to the literature, the critical relevance of KC-IT is highly associated with digital innovation (DI) for organisational success. However, DI is not yet a fully-fledged research subject but is an evolving corpus of theory and practise that draws from a variety of social science fields.
View Article and Find Full Text PDFTau acts as a mediator for Alzheimer's disease-related synaptic deficits.
Eur J Neurosci
April 2014
Department of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA; N. Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN, USA.
The two histopathological hallmarks of Alzheimer's disease (AD) are amyloid plaques containing multiple forms of amyloid beta (Aβ) and neurofibrillary tangles containing phosphorylated tau proteins. As mild cognitive impairment frequently occurs long before the clinical diagnosis of AD, the scientific community has been increasingly interested in the roles of Aβ and tau in earlier cellular changes that lead to functional deficits. Therefore, great progress has recently been made in understanding how Aβ or tau causes synaptic dysfunction.
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