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Combined Use of Intranasal Methylprednisolone and Allopregnanolone: Revisiting Anti-inflammatory and Remyelinating Treatment in a Murine Model of Multiple Sclerosis.
Front Biosci (Landmark Ed)
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Department of Immunology, Institute of Biomedical Research Universidad Nacional Autónoma de México, UNAM, 04510 Mexico City, Mexico.
Background: Multiple sclerosis (MS) is a demyelinating, neuroinflammatory, progressive disease that severely affects human health of young adults. Neuroinflammation (NI) and demyelination, as well as their interactions, are key therapeutic targets to halt or slow disease progression. Potent steroidal anti-inflammatory drugs such as methylprednisolone (MP) and remyelinating neurosteroids such as allopregnanolone (ALLO) could be co-administered intranasally to enhance their efficacy by providing direct access to the central nervous system (CNS).
View Article and Find Full Text PDFCytoprotective Effects and Intranuclear Localization of Sulfur-Containing Derivative of Buckminsterfullerene.
Front Biosci (Landmark Ed)
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Research Centre for Medical Genetics, 115522 Moscow, Russia.
Background: There is a growing interest in exploring the biological characteristics of nanoparticles and exploring their potential applications. However, there is still a lack of research into the potential genotoxicity of fullerene derivatives and their impact on gene expression in human cells. In this study, we investigated the effects of a water-soluble fullerene derivative, C60[C6H4SCH2COOK]5H (F1), on human embryonic lung fibroblasts (HELF).
View Article and Find Full Text PDFTuning the Selectivity in the Nonoxidative Alkane Dehydrogenation Reaction by Potassium-Promoted Zeolite-Encapsulated Pt Catalysts.
JACS Au
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Department of Chemistry and Engineering Research Center of Advanced Rare-Earth Materials of Ministry of Education, Tsinghua University, Beijing 100084, P. R. China.
The significance of the nonoxidative dehydrogenation of middle-chain alkanes into corresponding alkenes is increasing in the context of the world's declining demands on transportation fuels and the growing demand for chemicals and materials. The middle-chain alkenes derived from the dehydrogenation reaction can be transformed into value-added chemicals in downstream processes. Due to the presence of multiple potential reaction sites, the reaction mechanism of the dehydrogenation of middle-chain alkanes is more complicated than that in the dehydrogenation of light alkanes, and there are few prior studies on elucidating their detailed structure-reactivity relationship.
View Article and Find Full Text PDFElectrochemical Synthesis of Zeolite Coatings with Controlled Crystal Polymorphism and Self-Regulating Growth.
JACS Au
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Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware DE 19716, United States.
Zeolite coatings are studied as molecular sieves for membrane separation, membrane reactors, and chemical sensor applications. They are also studied as anticorrosive films for metals and alloys, antimicrobial and hydrophobic films for heating, ventilation, and air conditioning, and dielectrics for semiconductor applications. Zeolite coatings are synthesized by hydrothermal, ionothermal, and dry-gel conversion approaches, which require high process temperatures and lengthy times (ranging from hours to days).
View Article and Find Full Text PDFRole of NaCO as Nucleation Seeds to Accelerate the CO Uptake Kinetics of MgO-Based Sorbents.
JACS Au
December 2024
Laboratory of Energy Science and Engineering, Department of Mechanical and Process Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, 8092 Zürich, Switzerland.
There is an urgent need for inexpensive, functional materials that can capture and release CO under industrial conditions. In this context, MgO is a highly promising, earth-abundant CO sorbent. However, despite its favorable carbonation thermodynamics and potential for high gravimetric CO uptakes, MgO-based CO sorbents feature slow carbonation kinetics, limiting their CO uptake during typical industrial contact times.
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