Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy. A double-blind cross-over study.

Pain

Departamento de Diabetes y Metabolismo de Lipidos, Instituto National de la Nutricion 'Salvador Zubiran,' Vasco de Quiroga 15, Delegation Tlalpan, Mexico City, D.F. 14000 Mexico.

Published: December 1985

AI Article Synopsis

  • A clinical trial tested the effectiveness of a nortriptyline-fluphenazine combination for treating painful diabetic polyneuropathy.
  • Participants reported significant reductions in pain and paresthesia on a visual analog scale.
  • While side effects occurred frequently, they were generally mild and did not cause most patients to stop using the medications.

Article Abstract

A controlled clinical trial on the efficacy of a nortriptyline-fluphenazine combination was carried out in patients with painful diabetic polyneuropathy. A visual analog scale was used to evaluate the relief of pain or paresthesia. Significant relief of both pain and paresthesia was obtained with this combination. The differences were statistically significant. Side effects were frequent but not usually severe enough to lead to cessation of these medications.

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http://dx.doi.org/10.1016/0304-3959(85)90010-7DOI Listing

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