Objective: To compare serum levels of pepsinogen I (PGI), pepsinogen II (PGII), and gastrin-17 (G-17) among patients with gastritis, gastric ulcer, and gastric cancer, and to assess the effectiveness of these biomarkers individually and in combination for screening gastric cancer.

Methods: Serum levels of PGI, PGII, and G-17 were measured using enzyme-linked immunosorbent assay (ELISA) in 50 patients with gastric cancer, 60 with chronic gastritis, and 60 with gastric ulcer from February 2020 to June 2021. The diagnostic value of these biomarkers was analyzed through sensitivity, specificity, and ROC curve assessments.

Results: Serum PGI levels were significantly lower in patients with advanced gastric cancer compared to those with early gastric cancer (P < .05), while PGII and G-17 levels were significantly higher in advanced-stage patients (P < .05). The combined ROC curve analysis of PGI, PGII, and G-17 yielded an area under the curve (AUC) of 0.933, indicating higher diagnostic accuracy than any of the markers alone. Statistically significant differences were noted between the combined and individual tests (Z = 2.376, P < .05). Patients with PGI levels lower than 17.21 ng/ml had a worse prognosis compared to those with higher levels. Similarly, patients with PGII levels greater than 74.65 ng/ml and G-17 levels greater than 17.03 pmol/L had poorer prognoses. Additionally, higher G-17 levels were associated with significantly lower serum PGI levels.

Conclusions: Patients with low expression of PGI have a poorer prognosis, and those with high expression of PGII and G-17 also have a poor prognosis. Combining the three indicators has clear value for the screening and prognostic evaluation of gastric cancer, making it worthy of clinical promotion and application.

Download full-text PDF

Source

Publication Analysis

Top Keywords

gastric cancer
24
pgii g-17
16
pgi pgii
12
g-17 levels
12
gastric
9
levels
9
pgi
8
pepsinogen pgi
8
screening gastric
8
serum levels
8

Similar Publications

Objective: Overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is thought to be more aggressive in gastric cancer. This study aimed to evaluate the predictability of HER2 status and other prognostic pathologic parameters using [F]FDG PET/CT and to investigate its impact on survival.

Methods: Pretreatment metabolic parameters measured by [F]FDG PET/CT as a prognostic factor were retrospectively evaluated in 117 HER2-analysed patients.

View Article and Find Full Text PDF

Background: Helicobacter pylori infection causes gastritis, peptic ulcers, and gastric cancer. The infection is typically acquired in childhood and persists throughout life. The major impediment to successful therapy is antibiotic resistance.

View Article and Find Full Text PDF

Effectiveness of Postoperative Dietary Intervention in Patients with Gastric Cancer who Underwent Gastrectomy: Quasi-Experimental Study Design.

Semin Oncol Nurs

December 2024

College of Nursing, Research Institute of Nursing Innovation, Kyungpook National University, Daegu, South Korea. Electronic address:

Objectives: This article aims to investigate the effects of a postoperative dietary intervention on fatigue, self-efficacy in managing gastrointestinal side effects, self-efficacy for nutritional management, self-care activity, and unmet nursing needs among patients with gastric cancer who have undergone gastrectomy.

Methods: We used a quasi-experimental study design (nonequivalent control group pretest-posttest). Data were collected from 59 patients with gastric cancer (30 in the experimental group and 29 in the control patients) hospitalized for gastrectomy in Daegu, South Korea.

View Article and Find Full Text PDF

Untangling rapunzel syndrome: A unique presentation of gastric trichobezoar.

Int J Surg Case Rep

December 2024

Department of Pathology, Health Plus Diagnostics, Gorakhpur, India.

Introduction And Importance: Rapunzel syndrome is a rare condition that results from trichotillomania (compulsive hair pulling) and trichophagia (hair eating), causing a trichobezoar (hairball) to form This syndrome typically affects young females with psychiatric conditions and presents with symptoms like chronic abdominal pain, nausea, vomiting, and malnutrition. The condition is often diagnosed late, leading to serious gastrointestinal complications.

Case Presentation: A 19-year-old female from a rural community presented with chronic abdominal pain, vomiting, and nutritional deficiencies, including scaly skin and koilonychia.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates how lymphovascular invasion (LVI) affects overall survival in gastric cancer patients at pN0 stage after they've undergone surgery to remove the tumor.
  • - Out of 497 patients reviewed, 19.9% had LVI, which was linked to significantly poorer survival rates; further analysis identified LVI and the number of examined lymph nodes as independent predictors of survival.
  • - The findings suggest that for better outcomes, it is crucial to dissect more than 15 lymph nodes during surgery for patients with pN0 stage gastric cancer, especially those with LVI.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!