AI Article Synopsis
- Researchers are developing wireless miniature pumps and valves for dental implants to enable precise and controlled liquid release for therapeutic use.
- These devices use a magnet-screw mechanism for pumping and a flexible magnetic valve to manage liquid flow, allowing for targeted delivery directly to the implant-bone interface.
- The technology has been successfully demonstrated in both dental models and porcine jawbones, showing promise for long-term biomedical applications with minimal invasiveness.
Article Abstract
Enabling minimally invasive and precise control of liquid release in dental implants is crucial for therapeutic functions such as delivering antibiotics to prevent biofilm formation, infusing stem cells to promote osseointegration, and administering other biomedicines. However, achieving controllable liquid cargo release in dental implants remains challenging due to the lack of wireless and miniaturized fluidic control mechanisms. Here wireless miniature pumps and valves that allow remote activation of liquid cargo delivery in dental implants, actuated and controlled by external magnetic fields (<65 mT), are reported. A magnet-screw mechanism in a fluidic channel to function as a piston pump, alongside a flexible magnetic valve designed to open and close the fluidic channel, is proposed. The mechanisms are showcased by storing and releasing of liquid up to 52 µL in a dental implant. The liquid cargos are delivered directly to the implant-bone interface, a region traditionally difficult to access. On-demand liquid delivery is further showed by a metal implant inside both dental phantoms and porcine jawbones. The mechanisms are promising for controllable liquid release after implant placement with minimal invasion, paving the way for implantable devices that enable long-term and targeted delivery of therapeutic agents in various bioengineering applications.
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|---|---|
| http://dx.doi.org/10.1002/adhm.202402373 | DOI Listing |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650432 | PMC |
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