Functionalized 5-aryldeazaalloxazines have been successfully synthesised through a one-pot, three-component reaction involving -dimethylbarbituric acid, an aromatic aldehyde and aniline. By utilizing readily available reagents, this approach opens up the opportunity for the efficient formation of a variety of 5-aryldeazaalloxazines bearing electron-donating or halogen groups. This practical method is characterised by atom economy and offers a direct route to the introduction of an aryl moiety into the C(5)-position of deazaalloxazines, thereby generating novel catalysts for photoredox catalysis without the need for subsequent purification. Thus, it significantly improves existing approaches.
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| http://dx.doi.org/10.3762/bjoc.20.161 | DOI Listing |
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