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The Counteracting Effects of Ang II and Ang-(1-7) on the Function andGrowth of Insulin-secreting NIT-1 Cells.
Curr Diabetes Rev
August 2024
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
Introduction: China now has the highest number of diabetes in the world. Angiotensin II (Ang II) causes insulin resistance by acting on the insulin signaling pathway of peripheral target tissues. However, its effect on islet β-cells remains unclear.
View Article and Find Full Text PDFLocal activation of the pulmonary extravascular angiotensin system induces epithelial apoptosis and lung fibrosis.
J Lung Pulm Respir Res
December 2018
Department of Pediatrics, Michigan State University, USA.
Previous work suggests that a local extravascular angiotensin system plays an important role in the development of pulmonary fibrosis through stimulation of alveolar epithelial cell (AEC) apoptosis and collagen deposition. To demonstrate a causative role for the local tissue angiotensin (ANG) system in lung fibrosis, we hypothesize that overexpression of the angiotensinogen (AGT) gene or pharmacologic elevation of lung tissue ANG II levels might cause apoptosis of AECs and lung fibrosis. ANGII levels were elevated in rat or mouse lung tissue by intratracheal instillation of either purified ANGII or an adenovirus expressing AGT, or by ubiquitous overexpression of AGT in transgenic mice.
View Article and Find Full Text PDFPressure-overload-induced angiotensin-mediated early remodeling in mouse heart.
PLoS One
September 2017
Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York, United States of America.
Our previous work on angiotensin II-mediated electrical-remodeling in canine left ventricle, in connection with a long history of other studies, suggested the hypothesis: increases in mechanical load induce autocrine secretion of angiotensin II (A2), which coherently regulates a coterie of membrane ion transporters in a manner that increases contractility. However, the relation between load and A2 secretion was correlative. We subsequently showed a similar or identical system was present in murine heart.
View Article and Find Full Text PDFBovine ovarian cells have (pro)renin receptors and prorenin induces resumption of meiosis in vitro.
Peptides
July 2016
Laboratory of Biotechnology and Animal Reproduction, BioRep, Federal University of Santa Maria, Roraima Avenue 1000, 97105-900, Veterinary Hospital, Santa Maria, RS, Brazil. Electronic address:
The discovery of a receptor that binds prorenin and renin in human endothelial and mesangial cells highlights the possible effect of renin-independent prorenin in the resumption of meiosis in oocytes that was postulated in the 1980s.This study aimed to identify the (pro)renin receptor in the ovary and to assess the effect of prorenin on meiotic resumption. The (pro)renin receptor protein was detected in bovine cumulus-oocyte complexes, theca cells, granulosa cells, and in the corpus luteum.
View Article and Find Full Text PDFIn vitro method of studying the angiotensin activity of chemical compounds.
Bull Exp Biol Med
November 2014
Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center, Volgograd, Russia.
We developed and tested an experimental model to study in vitro the type 1 angiotensin antagonistic activity of compounds on the isolated portal vein of rats. The reliability of this method was confirmed in tests with saralasin (nonselective antagonist of angiotensin receptors) and losartan (selective antagonist of type 1 angiotensin receptors) in concentrations of 10(-9)-10(-5) mol/liter. The half-maximal inhibitory concentrations (IC50) of these substances were calculated.
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