AI Article Synopsis
- * There was a notable increase in bacteremia cases during the COVID-19 pandemic, with a 140% rise, while fatality and persistence of bacteremia were also significant concerns.
- * Genomic analyses showed higher prevalence of antibiotic resistance genes (like methicillin and macrolide) in pandemic isolates, indicating the bacteria's adaptation to the unique pressures caused by COVID-19 treatment practices.
Article Abstract
Genomic analyses of bacterial isolates are effective to compare the prevalence of antibiotic resistance genes and virulence determinants in different contexts. This study provides a comprehensive genomic description of 339 strains isolated from patients with bacteremia (2014-2022). Nosocomial acquisition accounted for 56.6% of cases, with vascular catheters being the main infection source (31.8%). Fatality (27.4%), persistent bacteremia (19.5%), and septic emboli (24.2%) were documented. During the COVID-19 pandemic, bacteremia episodes increased by 140%. Genetic features in pandemic isolates revealed higher prevalence of methicillin () and macrolide ( and ) resistance genes. Additionally, genes encoding clumping factors A and B, involved in fibrinogen binding, were more prevalent. This was linked to extensive macrolide use in COVID-19 accessory therapy and elevated fibrinogen levels in SARS-CoV-2 infection. These findings highlight adaptation to COVID-19 selective pressures and the value of whole-genome sequencing in molecular epidemiology studies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11301081 | PMC |
| http://dx.doi.org/10.1016/j.isci.2024.110402 | DOI Listing |
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