Background: Circadian rhythms impact metabolism and the therapeutic effects of drugs. The purpose of this study was to determine the association between and polymorphisms and caffeine citrate treatment response in infants with apnea of prematurity.
Methods: A total of 221 preterm infants of gestational age <34 weeks were included in this study (160 in the response group and 61 in the non-response group). The propensity score matching method was used to perform a 1:1 matching for all premature infants, and the general characteristics and clinical outcomes of the two groups were compared. The association between polymorphisms of the circadian transcription repressors and and caffeine citrate treatment response in infants with apnea of prematurity was analyzed with co-dominant, dominant, recessive, and over-dominant models, as well as analysis of alleles. Generalized multifactor dimensionality reduction (GMDR) analysis was used to analyze the interaction between the and genes.
Results: After propensity score matching, 45 preterm infants were included in each of the response and non-response groups, and there were no statistically significant differences in general characteristics between the two groups (> 0.05). Infants in the non-response groups had a higher incidence of moderate and severe bronchopulmonary dysplasia (BPD) (= 0.043), retinopathy of prematurity (ROP) (= 0.035), and invasive ventilation (= 0.027), and their duration of oxygen use (= 0.041) was longer. When corrected for false discovery rate, the rs228669 recessive model ( = 0.045) and the over-dominant model ( = 0.045) were both associated with caffeine citrate treatment response. Preterm infants with the rs228669 CC genotype had a significantly lower rate of caffeine citrate non-response in the recessive model (OR = 0.28, 95% CI = 0.12-0.66), which was significantly higher in preterm infants with the CT genotype in the over-dominant model (OR = 4.18, 95% CI = 1.64-10.66). GMDR analysis revealed an interaction between the and genes (< 0.05).
Conclusions: Circadian rhythms may play a role in the response of premature infants to caffeine citrate, and polymorphisms of the and genes may influence the effectiveness of caffeine citrate treatment for apnea of prematurity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11301747 | PMC |
| http://dx.doi.org/10.3389/fped.2024.1414185 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The association of gene polymorphisms of adenosine and dopamine receptors with the response to caffeine citrate treatment in infants with apnea of prematurity: a prospective nested case-control study.
Ital J Pediatr
October 2024
Department of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, Fujian, China.
Article Synopsis
- The study examines how variations in adenosine and dopamine receptor genes, along with clinical factors, affect how preterm infants respond to caffeine citrate treatment for apnea of prematurity (AOP).
- It analyzed data from 221 preterm infants, identifying 160 as responders to treatment and 61 as non-responders, while genotyping 22 genetic polymorphisms to compare outcomes.
- Findings showed that non-responders had higher rates of complications and specific genetic variations linked to poor response, while greater gestational age was identified as a protective factor; a predictive nomogram for treatment response was also developed.
Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.
Stroke
November 2024
Department of Pediatrics (J.K.M., Y.W., J.H., A.I., C.H., R.S.H., C.V., H.M., J.L.-B., J.R.F., D.M.F., E.M.), University of California San Francisco.
Article Synopsis
- Neonatal hypoxic-ischemic encephalopathy primarily impacts low- and middle-income countries, with therapeutic hypothermia often proving ineffective, highlighting a need for earlier treatment strategies.
- A study involved administering perinatal caffeine to near-term lambs undergoing severe hypoxia-ischemia, assessing its pharmacokinetics, safety, and efficacy in improving outcomes.
- Caffeine administration enhanced neurodevelopmental results and decreased inflammation and gray matter damage, suggesting it could be a viable treatment for affected neonates compared to previous studies on other medications.
Neonatal encephalopathy due to suspected hypoxic ischemic encephalopathy: pathophysiology, current, and emerging treatments.
World J Pediatr
November 2024
SAMRC Extramural Unit for Stem Cell Research and Therapy, Department of Immunology, Faculty of Health Sciences, Institute for Cellular and Molecular Medicine, University of Pretoria, Room 5-64, Level 5, Pathology Building, 15 Bophelo Road (Cnr. Steve Biko and Dr. Savage Streets), Prinshof Campus, Gezina, Pretoria, South Africa.
Background: Neonatal encephalopathy (NE) due to suspected hypoxic-ischemic encephalopathy (HIE), referred to as NESHIE, is a clinical diagnosis in late preterm and term newborns. It occurs as a result of impaired cerebral blood flow and oxygen delivery during the peripartum period and is used until other causes of NE have been discounted and HIE is confirmed. Therapeutic hypothermia (TH) is the only evidence-based and clinically approved treatment modality for HIE.
View Article and Find Full Text PDFDevelopment and application of a population pharmacokinetic model repository for caffeine dose tailoring in preterm infants.
Expert Opin Drug Metab Toxicol
September 2024
Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, China.
Background: Considerable interindividual variability for the pharmacokinetics of caffeine in preterm infants has been demonstrated, emphasizing the importance of personalized dosing. This study aimed to develop and apply a repository of currently published population pharmacokinetic (PopPK) models of caffeine in preterm infants to facilitate model-informed precision dosing (MIPD).
Research Design And Methods: Literature search was conducted using PubMed, Embase, Scopus, and Web of Science databases.
Association between PER and CRY gene polymorphisms and the response to caffeine citrate treatment in infants with apnea of prematurity.
Front Pediatr
July 2024
Department of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China.
Background: Circadian rhythms impact metabolism and the therapeutic effects of drugs. The purpose of this study was to determine the association between and polymorphisms and caffeine citrate treatment response in infants with apnea of prematurity.
Methods: A total of 221 preterm infants of gestational age <34 weeks were included in this study (160 in the response group and 61 in the non-response group).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!