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Epithelial misplacement in Peutz-Jeghers polyps-the efficacy of the distribution of immunohistochemical markers in its diagnosis.
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October 2024
Pathology Department, St Vincent's University Hospital, Dublin, Ireland.
My approach to assessing for colorectal polyp cancer.
J Clin Pathol
November 2024
Department of Cellular Pathology, Southmead Hospital, Bristol, UK
Assessing a locally excised colorectal adenoma for malignancy is a common but often challenging scenario. This article outlines a simple, stepwise approach to this diagnostic assessment. The first steps are to assess for high-grade dysplasia and, if present, to determine whether any neoplastic glands lie within the submucosa.
View Article and Find Full Text PDFImaging of colorectal adenomas with pseudoinvasion and malignant polyps using two-photon excitation microscopy.
Front Oncol
June 2024
Pathology Department, University of Medicine and Pharmacy, Carol Davila', Bucharest, Romania.
Introduction: Although the incidence and mortality rates of colorectal cancer exhibit significant variability, it remains one of the most prevalent cancers worldwide. Endeavors to prevent colorectal cancer development focus on detecting precursor lesions during colonoscopy. The diagnosis of endoscopically resected polyps relies on hematoxylin and eosin staining examination.
View Article and Find Full Text PDFDynein directs prophase centrosome migration to control the stem cell division axis in the developing Caenorhabditis elegans epidermis.
Genetics
March 2024
i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135, Portugal.
The microtubule motor dynein is critical for the assembly and positioning of mitotic spindles. In Caenorhabditis elegans, these dynein functions have been extensively studied in the early embryo but remain poorly explored in other developmental contexts. Here, we use a hypomorphic dynein mutant to investigate the motor's contribution to asymmetric stem cell-like divisions in the larval epidermis.
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