Background: This study aimed to identify postoperative recurrence and prognostic factors, including osteosarcopenia for borderline resectable (BR) and unresectable locally advanced (UR-LA) pancreatic cancer and to examine the impact of postoperative pancreatic enzyme replacement therapy (PERT).
Methods: We retrospectively examined 32 resected patients with BR and UR-LA pancreatic cancer. We investigated independent factors in the disease-free survival and overall survival. The relation of osteosarcopenia with the clinicopathological factors was investigated. Additionally, the association of the administration of a standard dose of pancrelipase, the amount of lipase required for patients with pancreatic exocrine insufficiency, for ≥6 months postoperatively with improvement of sarcopenia, osteopenia, and osteosarcopenia and completion rate of adjuvant chemotherapy was investigated.
Results: Multivariate analyses identified osteosarcopenia ( = 0.049) and lymph node metastasis ( = 0.01) as independent recurrence predictors, and osteosarcopenia ( = 0.002), maximum tumor diameter ≥40 mm ( = 0.006), and no adjuvant therapy ( = 0.01) as independent prognostic predictors. In the osteosarcopenia group, serum CA19-9 levels were higher ( = 0.03). The administration of a standard dose of pancrelipase for ≥6 months postoperatively was none in the osteosarcopenia group (0% vs 42.9%, = 0.01), while significantly improved postoperative sarcopenia (33% vs 0%, = 0.004), increased number of cycles of adjuvant chemotherapy (n = 6 vs n = 3, = 0.03), and the completion rate of adjuvant chemotherapy in excluding cases interrupted because of recurrence (86% vs 25%, = 0.007).
Conclusions: Osteosarcopenia was an independent recurrent and prognostic factor in patients after pancreatectomy for locally advanced pancreatic cancer. Appropriate postoperative PERT may contribute to a better prognosis by improving sarcopenia and increasing the completion rate of adjuvant chemotherapy.
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http://dx.doi.org/10.1177/00031348241272420 | DOI Listing |
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