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Penetratin and Mannose-Functionalized Cannabidiol Lipid Nanoparticles Encapsulating the BDNF Gene Reduce Amyloid-Induced Inflammation.
Mol Pharm
January 2025
Department of Pharmaceutical Sciences, School of Pharmacy, College of Health and Human Sciences, North Dakota State University, Fargo, North Dakota 58105, United States.
Inflammation is emerging as a critical player in the disease progression of Alzheimer's disease (AD) by its interaction with amyloid beta plaques in a feed-forward loop. There is also a decline in the nourishment and enriching neurotrophic factor, brain-derived neurotrophic factor (BDNF), in the brain. Therefore, supplementing the brain with BDNF by gene delivery and delivering the anti-inflammatory agent, cannabidiol (CBD) in this case, to mitigate inflammation-induced disease cascade offers an attractive treatment strategy.
View Article and Find Full Text PDFGlial fibrillary acidic protein and S100b protein immunoreactivity in the hippocampus of weaning rats from dams treated with acrylamide during pregnancy.
Folia Neuropathol
November 2024
Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland.
Acrylamide is formed at high temperature during preparation of food rich in carbohydrates. It can be found in animal feed based on potatoes and granulated wheat subjected to thermal treatment. It was demonstrated that acrylamide has a neurotoxic effect in newborn animals in both the central and peripheral nervous system after prenatal exposure to this substance.
View Article and Find Full Text PDFIntriguing astrocyte responses in CA1 to reduced and rehabilitated masticatory function: Dorsal and ventral distinct perspectives in adult mice.
Arch Oral Biol
January 2025
Laboratório de Investigações em Neurodegeneração e Infecção, Instituto de Ciências Biológicas, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, PA 66073-005, Brazil. Electronic address:
Article Synopsis
- This study examined how different diets affect the shape of astrocytes, a type of brain cell, in the CA1 region of mice brains over a six-month period.
- Three diets were tested: a hard pellet diet, a mixed hard/soft diet, and a rehabilitated hard diet, with analysis of astrocytes conducted post-euthanasia.
- Results indicated that dietary changes significantly impacted astrocyte morphology, particularly showing that the dorsal region's changes were reversible, whereas the ventral region experienced lasting effects which were linked to behavioral performance.
Neurotoxic mechanisms of mycotoxins: Focus on aflatoxin B1 and T-2 toxin.
Environ Pollut
September 2024
College of Veterinary Medicine, China Agricultural University, Haidian, Beijing, 100193, China. Electronic address:
Aflatoxin B1 (AFB1) and T-2 toxin are commonly found in animal feed and stored grain, posing a serious threat to human and animal health. Mycotoxins can penetrate brain tissue by compromising the blood-brain barrier, triggering oxidative stress and neuroinflammation, and leading to oxidative damage and apoptosis of brain cells. The potential neurotoxic mechanisms of AFB1 and T-2 toxin were discussed by summarizing the relevant research reports from the past ten years.
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