The authors study the role of thiamine-deficient diets in genetic variations contributing to Wernicke-Korsakoff syndrome.
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| http://dx.doi.org/10.1111/j.1530-0277.1979.tb05286.x | DOI Listing |
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Thiamine and Thiamine Pyrophosphate as Non-Competitive Inhibitors of Acetylcholinesterase-Experimental and Theoretical Investigations.
Molecules
January 2025
Chair and Department of Biochemistry and Pharmacogenomics, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
Vitamin B (thiamine) plays an important role in human metabolism. It is essential for the proper growth and development of the body and has a positive effect on the functioning of the digestive, cardiovascular, and nervous systems. Additionally, it stimulates the brain and improves the psycho-emotional state.
View Article and Find Full Text PDFWernicke's encephalopathy presenting with confusion and hearing loss.
BMJ Case Rep
January 2025
Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
We present a case of a male in his early 50s assessed in the emergency department with a seemingly clear alcohol history but with classic symptoms of Wernicke's encephalopathy (WE): disorientation, gait ataxia and vertical nystagmus. He also had significant bilateral hearing loss and profound anterograde amnesia. Neuroimaging revealed hallmark signs of WE, including symmetrical T2/fluid-attenuated inversion recovery hyperintensity in the medial thalami.
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Palliat Support Care
January 2025
Department of Psycho-Oncology, Saitama Medical University International Medical Center, Saitama, Japan.
Objectives: Wernicke encephalopathy (WE) is an acute neuropsychiatric disorder caused by thiamine deficiency. The classical triad of symptoms for WE include mental status changes, ataxia, and ophthalmoplegia. In contrast, more uncommon symptoms include hallucinations.
View Article and Find Full Text PDFSudden vision loss in pregnancy: Wernicke's encephalopathy in a patient with hyperemesis gravidarum.
BMJ Case Rep
December 2024
Ophthalmology, Kasturba Medical College Mangalore, Mangalore, Karnataka, India.
Wernicke's encephalopathy, the acute phase of Wernicke-Korsakoff syndrome, is characterised as a triad of altered mental status, ocular signs and ataxia. Our patient presented with hyperemesis gravidarum, which is a rare aetiology of Wernicke's encephalopathy. The patient did not have any oculomotor abnormalities, which are more common and classically described in Wernicke's triad.
View Article and Find Full Text PDFTowards a Non-pharmacological Intervention on Apathy in Korsakoff's Syndrome: A Systematic Narrative Review Across Different Clinical Conditions.
Neuropsychiatr Dis Treat
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Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Article Synopsis
- * This review examines the effectiveness of non-pharmacological interventions for apathy across different conditions similar to KS, including dementia, Parkinson's disease, schizophrenia, and traumatic brain injury, drawing on 22 systematic reviews and 32 empirical studies.
- * Successful interventions for severely cognitively impaired individuals rely on external stimulation rather than intrinsic motivation, highlighting the need to tailor treatments to the individual's interests and assess the specific apathetic behaviors before starting any intervention.
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