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Blood cortisol and faecal cortisol metabolite concentrations following an ACTH challenge in unanaesthetized brown bears ().
Conserv Physiol
January 2025
Wildlife Ecology and Conservation Science Lab, Department of Biology, Northern Michigan University, 1401 Presque Isle Ave, Marquette, MI 49855-5301, USA.
Faecal cortisol metabolites (FCMs) are increasingly used to index physiological stress in wildlife. Cortisol and other stress hormones act to mobilize glucose, providing energy for the organism to respond to environmental perturbations. Cortisol, the predominant glucocorticoid (GC) in most mammals, is metabolized by the liver and excreted as FCMs.
View Article and Find Full Text PDFCD44 in myEloid cells is a major driver of liver inflammation and injury in alcohol-related liver disease.
Hepatology
January 2025
Université Côte d'Azur, INSERM, U1065, C3M, Nice, France.
Background And Aims: Alcohol-related liver disease (ALD) is one of the leading causes of severe liver disease with limited pharmacological treatments for alcohol-related steatohepatitis (ASH). CD44, a glycoprotein mainly expressed in immune cells, has been implicated in multiple inflammatory diseases but has never been studied in the ALD context. We therefore studied its contribution to ASH development in mice and its expression in ALD patients.
View Article and Find Full Text PDFHepatic lipid accumulation, or Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), is a significant risk factor for liver cancer. Despite the rising incidence of MASLD, the underlying mechanisms of steatosis and lipotoxicity remain poorly understood. Interestingly, lipid accumulation also occurs during fasting, driven by the mobilization of adipose tissue-derived fatty acids into the liver.
View Article and Find Full Text PDFA comparative analysis of unilateral biportal endoscopic and open laminectomy in multilevel lumbar stenosis.
Front Neurol
December 2024
Department of Spine Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China.
Background: Approximately 103 million people across the globe suffer from symptomatic lumbar spinal stenosis, impacting their health and quality of life. The unilateral biportal endoscopic technique is effective for treating single-segment degenerative lumbar spinal stenosis and is seen as a viable alternative to traditional open lumbar laminectomy. However, research on the application of this technique for multilevel lumbar spinal stenosis remains lacking.
View Article and Find Full Text PDFLaparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava: A retrospective cohort study.
World J Gastroenterol
January 2025
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China.
Background: Laparoscopic liver resection (LLR) can be challenging due to the difficulty of establishing a retrohepatic tunnel under laparoscopy. Dissecting the third hepatic hilum before parenchymal transection often leads to significant liver mobilization, tumor compression, and bleeding from the short hepatic veins (SHVs). This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava (IVC), allowing SHVs to be addressed after parenchymal transection, thereby reducing surgical complexity and improving outcomes in in situ LLR.
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