Purpose: To evaluate the effects of pupil dilation caused by topical applications of 2.5% phenylephrine and 0.5% tropicamide on retinal microvascularization using optical coherence tomography angiography (OCTA).
Methods: Healthy children were included in this prospective observational study. Baseline OCTA measurements were taken for all children before dilatation. Then they were randomly divided into two groups, the tropicamide group given 0.5% tropicamide solution and the phenylephrine group given 2.5% phenylephrine solution. After dilation OCTA images were taken for the second time from all children.
Results: The effect of dilation using two different mydriatic agents caused a decrease in mean radial peripapillary capillary density (RPC-VD) and superior RPC-VD (p=0.008 and p=0.001). Remarkably, this reduction due to dilatation was also determined to be caused by the combined effect of both mydriatic agents (p=0.016 and p=0.013). Although phenylephrine showed a slightly greater decrease than tropicamide, the effects of the two mydriatic drugs were not superior to each other (p=0.166 and p=0.167).
Conclusion: Dilation with 2.5% phenylephrine or 0.5% tropicamide significantly decreased mean RPC-VD and superior RPC-VD. Although there was no statistically significant difference between the two mydriatic agents, phenylephrine caused a greater reduction than tropicamide. This effect of dilation and phenylephrine on VD should be considered in studies using OCTA and focusing on peripapillary areas.
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http://dx.doi.org/10.1097/IAE.0000000000004230 | DOI Listing |
J Zoo Wildl Med
December 2024
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
American alligators () are an important apex predator of semiaquatic habitats of the southern United States. Commercial alligator farming has grown in the last several decades, leading to a need to understand the health conditions that affect this species to ensure appropriate management and welfare. The aims of this study were 1) to establish and describe normative data including results of common ophthalmic diagnostic tests and conjunctival flora, 2) document ocular pathology in this population, and 3) assess the effect of topical rocuronium bromide and 10% phenylephrine for facilitating pharmacologic mydriasis.
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Biomedical Sciences Program, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.
Marfan syndrome (MFS) is a systemic connective tissue disorder stemming from mutations in the gene encoding Fibrillin-1 (Fbn1), a key extracellular matrix glycoprotein. This condition manifests with various clinical features, the most critical of which is the formation of aortic root aneurysms. Reduced nitric oxide (NO) production due to diminished endothelial nitric oxide synthase (eNOS) activity has been linked to MFS aortic aneurysm pathology.
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Department of Anesthesia, Hangzhou City Linping District Maternal and Children Care Hospital, Hangzhou, China.
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Department of Anaesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Carcinoid crisis is a potentially fatal condition with severe hemodynamic instability. A 25-year-old female with metastatic pancreatic neuroendocrine tumor with recurrent carcinoid crises was posted for surgical debulking. Intraoperatively, the patient was on crisis during manipulation of the lesion by the surgeon, which was unresponsive to octreotide, infusions of phenylephrine, and norepinephrine agents.
View Article and Find Full Text PDFVopr Pitan
November 2024
Pavlov Institute of Physiology, Russian Academy of Sciences, 199034, Saint Petersburg, Russian Federation.
Excessive fat intake causes the development of metabolic syndrome (MS). Our studies have shown that soy proteins in the diet improve vascular reactivity in rats with a high-salt dietary load and renal dysfunction. We hypothesized that the introduction of soy proteins into a high-fat diet (HFD) can prevent or reduce vascular dysfunction.
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