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Introduction of Ivacaftor/Lumacaftor in Children With Cystic Fibrosis Homozygous for F508del in the Netherlands: A Nationwide Real-Life Study.
Pediatr Pulmonol
January 2025
Beatrix Children's Hospital Department of Pediatric Pulmonology and Pediatric Allergy, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Introduction: Lumacaftor/ivacaftor (lum/iva) was introduced in the Netherlands in 2017. We investigated 1-year efficacy of lum/iva on lung function and small airway and structural lung disease evaluated by multiple breath nitrogen washout and CT scan. Additionally, we investigated effects of lum/iva on exacerbations, anthropometry, sweat chloride and safety in children with CF in the Netherlands.
View Article and Find Full Text PDFDirect Printing of an Electrochemical Device and Its Interface with Paper for Uric Acid Detection in Human Sweat.
ACS Appl Bio Mater
January 2025
Department of Medical Devices, National Institute of Pharmaceutical Education and Research, Guwahati, Assam 781101, India.
Using a laser-scribed (direct printing) technique, we have fabricated an enzymeless, mediatorless, and paper-interfaced electrochemical device (P-LSG) for uric acid detection on a flexible polyimide sheet. Various paper substrates were investigated, and it was found that Whatman filter paper-1 is promising to obtain the best electrochemical signals at the small volume of electrolyte, i.e.
View Article and Find Full Text PDF7 days of L-citrulline supplementation does not improve running performance in the heat whilst in a hypohydrated state.
Eur J Appl Physiol
December 2024
National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Purpose: 7 days L-citrulline supplementation has been reported to improve blood pressure, O kinetics, gastrointestinal (GI) perfusion and endurance cycling performance through increasing arterial blood flow. In situations where blood volume is compromised (e.g.
View Article and Find Full Text PDFMild hypohydration in healthy older adults increases pain-related brain activity without affecting pain perception: a single-blind study.
J Appl Physiol (1985)
January 2025
Faculty of Physical Activity Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Understanding how hydration status influences pain perception is particularly important in older adults, as both dehydration and pain are prevalent in this population. Ten individuals (70 ± 4 yr) completed two randomized and counterbalanced trials. They were exposed to passive heat until they lost 1% body mass through sweat and urine (∼100 min), with the loss either unreplaced (sham infusion, HYPO) or fully replaced via 0.
View Article and Find Full Text PDFRecent Advances in Nanomaterial-Based Biosignal Sensors.
Small
November 2024
Applied Nano and Thermal Science Lab, Department of Mechanical Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
Article Synopsis
- - Recent advancements in medical, robotics, and wearable tech focus on biosignal sensors that collect biological data for evaluating well-being, predicting behavior, and aiding in disease management.
- - The review categorizes these sensors into three types: biophysical (detecting physical changes), bioelectric (measuring electrical signals from the body), and biochemical (analyzing biological fluids), while discussing their limitations and potential improvements.
- - The paper emphasizes the role of deep learning in processing biosignals and improving human-machine interactions, aiming to better the understanding and future development of nanomaterial-based biosignal sensors.
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