pneumonia (PCP), now referred to as pneumonia (PJP), occurs in immunocompromised patients. It is particularly associated with cellular immunodeficiency due to certain diseases or treatments. The risk of PCP is likely correlated with the severity of cellular immunity damage. However, excluding AIDS, the precise degree of immunosuppression required to develop PCP is not yet clearly understood. We report the case of a 58-year-old patient who presented with progressively worsening dyspnea. The clinical examination revealed a SaO₂ of 88% on room air and the appearance of mechanic's hands. A thoracic CT scan showed interstitial lung disease (ILD). The immunological work-up was positive for antinuclear antibodies (ANA) and anti-JO-1 antibodies. Bronchoscopy with bronchoalveolar lavage (BAL) was performed, and the test for PJP came back positive.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299875 | PMC |
http://dx.doi.org/10.7759/cureus.63982 | DOI Listing |
Beijing Da Xue Xue Bao Yi Xue Ban
December 2024
Department of Rheumatology and Immunology, Peking University People' s Hospital, Beijing 100044, China.
J Inflamm Res
November 2024
Department of Clinical Laboratory, the First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, Nanning, Guangxi, 530021, People's Republic of China.
Arthritis Res Ther
December 2024
Division of Rheumatology, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, 171 64, Solna, Stockholm, Sweden.
Intern Med J
November 2024
Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Western Australia, Australia.
Front Immunol
November 2024
Department of Rheumatology and Immunology, Tianjin Medical University General Hospital, Tianjin, China.
Objectives: The objective of this study was to profile the transcriptional profiles of peripheral blood mononuclear cells (PBMCs) and their immune repertoires affected by anti-synthetase syndrome (ASS) at the single-cell level.
Methods: We performed single-cell RNA sequencing (scRNA-seq) analysis of PBMCs and bulk RNA sequencing for patients with ASS (N=3) and patients with anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5 DM, N=3) along with healthy controls (HCs, N=4). As ASS and MDA5 DM have similar organ involvements, MDA5 DM was used as a disease control.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!