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A case of Rowell syndrome after a herpes simplex infection and prolonged sun exposure. | LitMetric

AI Article Synopsis

  • Rowell Syndrome is a rare condition that combines features of erythema exudativum multiforme (EEM) and lupus erythematosus (LE).
  • The new diagnostic criteria include three major criteria (different types of LE, EEM-like skin lesions, and a specific antibody pattern) and several minor criteria (chilblains and certain positive antibody tests).
  • Treatment options are similar to those for EEM and LE, often showing positive results with medications like oral cortisone and azathioprine, and the presented case showed good improvement with topical treatments following a herpes infection and sun exposure.

Article Abstract

Rowell Syndrome is a rare entity combining erythema exudativum multiforme (EEM) and lupus erythematosus (LE). Zeitouni et al. redefined Rowell Syndrome's diagnostic criteria. Major criteria include: (1) LE (systemic, discoid or subacute cutaneous), (2) EEM-like skin lesions and (3) speckled pattern of antinuclear antibodies. Minor criteria comprise: (1) chilblains, (2) positive anti-SSA/Ro or anti-SSB/La antibodies and (3) positive rheumatoid factor. The diagnosis is achieved when all major criteria and at least one minor criterion are present. Prognosis and treatment regimens are those of EEM and LE, with reported good response to oral cortisone, azathioprine, cyclosporine, dapsone, antimalarials and methotrexate. We present a case of Rowell Syndrome in a young adult after a herpes simplex type 1 infection and unprotected sun exposure, with good response to both topical corticosteroids and calcineurin-inhibitors.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297421PMC
http://dx.doi.org/10.1002/ski2.378DOI Listing

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