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Effect of Intravenous Paracetamol on Postoperative Recovery in Children Undergoing Hypospadias Repair under General Anaesthesia with Caudal Block: A Randomised Controlled Trial.
J Coll Physicians Surg Pak
January 2025
Department of Anaesthesiology, The Aga Khan University and Hospital, Karachi, Pakistan.
Objective: To explore the impact of perioperative intravenous (IV) paracetamol, administered with caudal ropivacaine on the quality of postoperative recovery in children undergoing hypospadias repair.
Study Design: Double-blinded randomised controlled trial. Place and Duration of the Study: The operating room, post-anaesthesia care unit (PACU), and paediatric surgical ward at the Aga Khan University Hospital, from 31st January 2019 to 1st May 2022.
Monitoring of drinking water quality: a preliminary approach by an electronic tongue based on functionalized polymer membrane electrodes.
Anal Methods
November 2017
Materials Science Centre, Indian Institute of Technology, Kharagpur-721302, India.
Functionalized polymer membrane electrodes based multichannel sensor is used as an electronic tongue to monitor the drinking water (DW) quality simply by measuring the surface electric potential with respect to Ag/AgCl reference electrode in 1 mM aqueous KCl. Changes of minute concentration of dissolved minerals greatly affected the surface potential of the sensor. The three-channel sensor device (electronic tongue) is made by using three different functionalized polymer membrane electrodes, namely, phosphorylated hexadecyl trimethyl ammonium chloride modified polyvinyl alcohol-polyacrylic acid membrane; phosphorylated and crosslinked polyvinyl--ethylene membrane; phosphorylated and crosslinked polyvinyl alcohol membrane, as working electrodes and a Ag/AgCl reference electrode.
View Article and Find Full Text PDFRepresentative Training Data Sets Are Critical for Accurate Machine-Learning Classification of Microscopy Images of Particles Formed by Lipase-catalyzed Polysorbate Hydrolysis.
J Pharm Sci
January 2025
Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303. Electronic address:
Polysorbate 20 (PS20) is commonly used as an excipient in therapeutic protein formulations. However, over the course of a therapeutic protein product's shelf life, minute amounts of co-purified host-cell lipases may cause slow hydrolysis of PS20, releasing fatty acids (FAs). These FAs may precipitate to form subvisible particles that can be detected and imaged by various techniques, e.
View Article and Find Full Text PDFTwo minutes is sufficient to characterize the viscoelastic properties of the human lower birth canal during the first stage of labor.
Clin Biomech (Bristol)
January 2025
Department of Mechanical Engineering, University of Michigan, 2350 Hayward St, Ann Arbor, MI 48109, United States; Department of Biomedical Engineering, University of Michigan, 200 Bonisteel Blvd, Ann Arbor, MI 48109, United States. Electronic address:
Background: The lower birth canal is the final constriction through which a fetal head must pass for delivery. Unfortunately, injuries to the lower birth canal tissues occur in up to 19 % of first-time vaginal deliveries due to the 300 % stretch required.
Methods: This is a secondary analysis of data from 56 healthy nullipara recorded by a lower birth canal dilator during the first stage of labor.
Improving Atrial Fibrillation or Flutter Detection and Management by Smartphone-Based Photoplethysmography Rhythm Monitoring Following Cardiac Surgery: A Pragmatic Randomized Trial.
Europace
January 2025
Department of Cardiovascular Sciences, UZ Leuven, Leuven, Belgium.
Background And Aims: Atrial fibrillation (AF) or atrial flutter (AFL) after cardiac surgery are common and associated with adverse outcomes. The increased risk related to AF or AFL may extend beyond discharge. This study aims to determine whether photoplethysmography (PPG)-based smartphone monitoring to detect AF or AFL after hospital discharge following cardiac surgery improves AF management.
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