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Efficacy of HBV booster dose administration in Italian medical students in relation to health determinants.
Hum Vaccin Immunother
December 2024
Department of Life, Health and Environmental Science, University of L'Aquila, L'Aquila, Italy.
Article Synopsis
- The study assessed the effectiveness of a booster HBV vaccine in Italian medical students, revealing that a significant portion had low antibody levels after 15 years.
- Out of 625 students, 355 were given a booster, and 92.77% of those who received it achieved adequate antibody levels after one month.
- Results showed that physical activity improved immune response to the booster, highlighting the importance of maintaining higher pre-booster antibody levels for better vaccine effectiveness.
Rituximab in Refractory Myasthenia Gravis - Challenges and Lessons Learnt.
Ann Indian Acad Neurol
November 2024
Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
Nearly 10%-15% patients with generalized myasthenia gravis (MG) have refractory disease and are candidates for newer nonconventional immunotherapies. Rituximab has emerged as an attractive option in them. We describe the efficacy and safety of rituximab in 12 patients with refractory MG treated over a period of 4 years in a tertiary care center.
View Article and Find Full Text PDFDelayed partial nephrectomy following complete response to immunotherapy: feasibility and results (UroCCR n°157).
Urol Oncol
November 2024
Bordeaux University Hospital, Urology department, Bordeaux, France; Kidney Cancer group of the French Association of Urology Cancer Committee, Paris, France.
Article Synopsis
- Metastatic kidney cancer patients who respond well to immunotherapy are being reconsidered for primary surgery, particularly nephron-sparing surgery, due to their prolonged survival.
- A study analyzed 13 patients who had partial nephrectomy after achieving complete responses to immunotherapy, finding no positive surgical margins and acceptable complication rates.
- Results showed promising renal function and oncological outcomes, indicating that partial nephrectomy is feasible after immunotherapy, but more research is necessary for definitive conclusions.
Impact of the COVID-19 Pandemic on People with Dementia and their Caregivers: A Multiphase Observational Study from India.
Curr Alzheimer Res
January 2025
Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore, Karnataka, Bangalore, India.
Introduction: The COVID-19 pandemic has had multifaceted and enduring impacts on people with dementia and their caregivers; however, our understanding of the long-term outcomes remains limited. We aimed to explore the long-term effects of the COVID-19 pandemic on cognitive symptoms and vaccination rates in people living with dementia.
Methods: This study was conducted as a part of a longitudinal study design in two specialized hospitals in South India.
Clinical presentation and treatment response in ACPA-negative rheumatoid arthritis.
Joint Bone Spine
November 2024
UMR 1227 Lymphocytes B, Auto-immunité et Immunothérapies, University Brest, Inserm, CHU de Brest, Brest, France.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation and potential extra-articular manifestations. This review compares the presentation and treatment response between anti-citrullinated protein antibodies (ACPA)-positive and ACPA-negative RA patients. The incidence of seronegative RA (rheumatoid factor [RF]-negative and ACPA-negative) has increased in recent decades, emphasizing the need for new diagnostic biomarkers.
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