AI Article Synopsis
- Rheumatoid arthritis (RA) is linked to increasing mortality rates, and dietary magnesium (Mg) is known to have anti-inflammatory effects, but its impact on RA patients' overall mortality is underexplored.
- A study using NHANES data from 1999-2018 focused on 2,952 RA patients, assessing their Mg intake and tracking mortality until the end of 2019 through various statistical models.
- Results indicated that higher dietary Mg intake was associated with an 11.12% reduction in all-cause mortality, particularly benefiting certain groups like younger patients and females.
Article Abstract
Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with all-cause mortality increasing globally. Dietary magnesium (Mg), an anti-inflammatory nutrient, has been proven to be associated with the all-cause mortality. The association of dietary Mg intake and all-cause mortality in RA patients remains unknown. The aim of this study was to assess the association between dietary Mg intake and all-cause mortality in RA patients.
Methods: RA patients were extracted from the NHANES 1999-2018, and followed for survival through December 31, 2019. Dietary Mg intake data were obtained from 24-h dietary recall interview. The association between dietary Mg intake and RA patients' all-cause mortality was explored based on weighted univariate and multivariate Cox proportional hazard models and described as absolute risk difference (ARD), hazard ratios (HRs) and 95% confidence intervals (CIs). This association was further explored in subgroup analyses based on different age, gender and body mass index (BMI).
Results: Totally 2,952 patients were included. Until 31 December 2019, a total of 825 deaths were documented. RA patients with higher dietary Mg intake had a 11.12% reduction of all-cause mortality (ARD=-11.12%; HR = 0.74, 95%CI: 0.56-0.99) in the fully adjusted model, especially in female (HR = 0.68, 95%CI: 0.47-0.98), aged < 65 years (HR = 0.59, 95%CI: 0.37-0.94) and BMI ≤ 30 kg/m (HR = 0.62, 95%CI: 0.42-0.91).
Conclusion: RA patients who consumed adequate dietary Mg from diet as well as supplements may had a lower risk of all-cause mortality.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302089 | PMC |
| http://dx.doi.org/10.1186/s41043-024-00597-1 | DOI Listing |
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